GSTM1 antibody (C-Term)

Catalog No. ABIN390883

This Rabbit Polyclonal antibody specifically detects GSTM1 in WB, IHC (p) and FACS. It exhibits reactivity toward Human and Mouseand has been mentioned in 1 publication.

Quick Overview for GSTM1 antibody (C-Term) (ABIN390883)

Target: GSTM1 (Glutathione S-Transferase mu 1 (GSTM1))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GSTM1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS)

Clone: RB21078

Product Details anti-GSTM1 Antibody

Binding Specificity: AA 184-211, C-Term

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This GSTM1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 184-211 amino acids from the C-terminal region of human GSTM1.

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000. IHC-P: 1:10~50. FC: 1:10~50

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

References for anti-GSTM1 antibody (ABIN390883)

Engman, Varghese, Lagerstedt Robinson, Malmgren, Hammarsjö, Byström, Lalitkumar, Gemzell-Danielsson: "GSTM1 gene expression correlates to leiomyoma volume regression in response to mifepristone treatment." in: PLoS ONE, Vol. 8, Issue 12, pp. e80114, (2013) (PubMed).

Target Details for GSTM1

Target: GSTM1 (Glutathione S-Transferase mu 1 (GSTM1))

Alternative Name: GSTM1

Background: GSTM1 is a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs.

Molecular Weight: 25712

Gene ID: 2944

NCBI Accession: NP_000552, NP_666533

UniProt: P09488

Pathways: Negative Regulation of Transporter Activity