PKC mu antibody (N-Term)

Catalog No. ABIN391011

This anti-PKC mu antibody is a Rabbit Polyclonal antibody detecting PKC mu in WB and IHC (p). Suitable for Human and Mouse. This Primary Antibody has been cited in 3+ publications.

Quick Overview for PKC mu antibody (N-Term) (ABIN391011)

Target: PKC mu (PRKD1) (Protein Kinase D1 (PRKD1))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PKC mu antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: RB1037

Product Details anti-PKC mu Antibody

Binding Specificity: AA 361-389, N-Term

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This PKC mu antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 361-389 amino acids from the N-terminal region of human PKC mu.

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000. IHC-P: 1:50~100

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

References for anti-PKC mu antibody (ABIN391011)

Spratley, Bastea, Döppler, Mizuno, Storz: "Protein kinase D regulates cofilin activity through p21-activated kinase 4." in: The Journal of biological chemistry, Vol. 286, Issue 39, pp. 34254-61, (2011) (PubMed).

Ivanova, Atanasova, Poumay, Mitev: "Knockdown of PKD1 in normal human epidermal keratinocytes increases mRNA expression of keratin 10 and involucrin: early markers of keratinocyte differentiation." in: Archives of dermatological research, Vol. 300, Issue 3, pp. 139-45, (2008) (PubMed).

Wu, Solaro: "Protein kinase C zeta. A novel regulator of both phosphorylation and de-phosphorylation of cardiac sarcomeric proteins." in: The Journal of biological chemistry, Vol. 282, Issue 42, pp. 30691-8, (2007) (PubMed).

Target Details for PKC mu

Target: PKC mu (PRKD1) (Protein Kinase D1 (PRKD1))

Alternative Name: PKC mu

Background: Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play distinct roles in cells. PKC mu is one of the PKC family members. The protein is a cytosolic serine-threonine kinase that binds to the trans-Golgi network and regulates the fission of transport carriers specifically destined to the cell surface.

Molecular Weight: 101704

Gene ID: 5587

NCBI Accession: NP_002733

UniProt: Q15139

Pathways: Myometrial Relaxation and Contraction