Complement Factor B antibody (Center)

Catalog No. ABIN391536

The Rabbit Polyclonal anti-Complement Factor B antibody (Clone RB18685) (ABIN391536) specifically detects Complement Factor B in WB and IHC (p). The antibody is reactive with Human samples.

Quick Overview for Complement Factor B antibody (Center) (ABIN391536)

Target: Complement Factor B (CFB)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Complement Factor B antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: RB18685

Product Details anti-Complement Factor B Antibody

Binding Specificity: AA 395-422, Center

Specificity: This BF antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 401~431 amino acids from the Center region of human BF.

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This BF antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 395-422 AA from the Central region of human BF.

Isotype: Ig Fraction

Application Details

Application Notes: WB = 1:1000, IHC (p) = 1:50-100

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 2 mg/mL

Buffer: PBS with 0.09 % (W/V) sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C/-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

Target Details for Complement Factor B

Target: Complement Factor B (CFB)

Alternative Name: Complement Factor B

Background: BF is complement factor B, a component of the alternative pathway of complement activation. Factor B circulates in the blood as a single chain polypeptide. Upon activation of the alternative pathway, it is cleaved by complement factor D yielding the noncatalytic chain Ba and the catalytic subunit Bb. The active subunit Bb is a serine protease which associates with C3b to form the alternative pathway C3 convertase. Bb is involved in the proliferation of preactivated B lymphocytes, while Ba inhibits their proliferation.
Synonyms: Complement factor B, C3/C5 convertase, Properdin factor B, Glycine-rich beta glycoprotein, GBG, PBF2, Complement factor B Ba fragment, Complement factor B Bb fragment, BFD, BF, CFB

Molecular Weight: 85533 DA

Gene ID: 629

UniProt: P00751

Pathways: Complement System, Proton Transport, Ribonucleoside Biosynthetic Process