PTK7 antibody (N-Term)

Catalog No. ABIN392230

This Rabbit Polyclonal antibody specifically detects PTK7 in WB, IHC (p) and FACS. It exhibits reactivity toward Humanand has been mentioned in 1 publication.

Quick Overview for PTK7 antibody (N-Term) (ABIN392230)

Target: PTK7 (PTK7 Protein tyrosine Kinase 7 (PTK7))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PTK7 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS)

Clone: RB01501

Product Details anti-PTK7 Antibody

Binding Specificity: AA 21-52, N-Term

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This CCK4 (PTK7) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 21-52 amino acids from the N-terminal region of human CCK4 (PTK7).

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000-1:2000. IHC-P: 1:50~100. FC: 1:10~50

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

References for anti-PTK7 antibody (ABIN392230)

Wang, Li, Yin, Wang, Wang, Wei, Guo, Ma, Shi, Zhou, Wang: "PTK7 protein is decreased in epithelial ovarian carcinomas with poor prognosis." in: International journal of clinical and experimental pathology, Vol. 7, Issue 11, pp. 7881-9, (2014) (PubMed).

Target Details for PTK7

Target: PTK7 (PTK7 Protein tyrosine Kinase 7 (PTK7))

Alternative Name: CCK4 (PTK7)

Background: CCK4 may function as a cell adhesion molecule. Although it belongs to the insuline receptor subfamily of the Tyr protein kinases, it likely lacks the catalytic activity of a tyrosine kinase. It may be connected to the pathophysiology of colon carcinomas and/or may represent a tumor progression marker. This Type I membrane protein is highly expressed in lung, liver, pancreas, kidney, placenta and melanocytes, but weakly expressed in thyroid gland, ovary, brain, heart and skeletal muscle, and not in colon. It is also expressed in erythroleukemia cells.

Molecular Weight: 118392

Gene ID: 5754

NCBI Accession: NP_001257327, NP_002812, NP_690619, NP_690620, NP_690621

UniProt: Q13308

Pathways: RTK Signaling, Tube Formation