NPR3 antibody (N-Term)

Catalog No. ABIN392706

Cited in 2+ publications. The Rabbit Polyclonal anti-NPR3 antibody (Clone RB03504) (ABIN392706) specifically detects NPR3 in WB, IF and IHC (p). The antibody is reactive with Human samples.

Quick Overview for NPR3 antibody (N-Term) (ABIN392706)

Target: NPR3 (Atrial Natriuretic Peptide Receptor 3 (NPR3))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NPR3 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: RB03504

Product Details anti-NPR3 Antibody

Binding Specificity: AA 67-97, N-Term

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This Natriuretic Peptide Receptor C antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 67-97 amino acids from the N-terminal region of human Natriuretic Peptide Receptor C.

Isotype: Ig Fraction

Application Details

Application Notes: IF: 1:200. WB: 1:1000. IHC-P: 1:10~50

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid freeze-thaw cycles.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots.

Expiry Date: 6 months

References for anti-NPR3 antibody (ABIN392706)

Loo, Shepherd, Mickle, Lorca, Shutov, Usachev, Mohapatra: "The C-type natriuretic peptide induces thermal hyperalgesia through a noncanonical G??-dependent modulation of TRPV1 channel." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 32, Issue 35, pp. 11942-55, (2012) (PubMed).

Liu, Abendschein, Woodard, Rossin, McCommis, Zheng, Welch, Woodard: "Molecular imaging of atherosclerotic plaque with (64)Cu-labeled natriuretic peptide and PET." in: Journal of nuclear medicine : official publication, Society of Nuclear Medicine, Vol. 51, Issue 1, pp. 85-91, (2010) (PubMed).

Target Details for NPR3

Target: NPR3 (Atrial Natriuretic Peptide Receptor 3 (NPR3))

Alternative Name: Natriuretic Peptide Receptor C (NPR3/ANPC)

Background: ANPC is a receptor for atrial natriuretic peptide. It does not exhibit guanylate cyclase activity. There seem to be at least three ANP receptors: two with guanylate cyclase activity (ANPA and ANPB) and one (ANPC) which is probably responsible for the clearance of ANP from the circulation without a role in signal transduction.

Molecular Weight: 59808

Gene ID: 4883

NCBI Accession: NP_000899, NP_001191304, NP_001191305

UniProt: P17342

Pathways: cAMP Metabolic Process