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MARK2 antibody (Isoform A, pThr595)

MARK2 Reactivity: Human, Mouse, Rat, Cow, Dog WB, EIA Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN401318
  • Target See all MARK2 Antibodies
    MARK2 (MAP/microtubule Affinity-Regulating Kinase 2 (MARK2))
    Binding Specificity
    • 13
    • 8
    • 8
    • 5
    • 5
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Isoform A, pThr595
    Reactivity
    • 74
    • 49
    • 40
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Human, Mouse, Rat, Cow, Dog
    Host
    • 70
    • 3
    • 1
    Rabbit
    Clonality
    • 62
    • 12
    Polyclonal
    Conjugate
    • 37
    • 5
    • 5
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    This MARK2 antibody is un-conjugated
    Application
    • 51
    • 37
    • 22
    • 16
    • 11
    • 10
    • 5
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Enzyme Immunoassay (EIA)
    Specificity
    This antibody is directed against the phosphorylated form of MARK2 at thepT595 residue.
    Cross-Reactivity (Details)
    Species reactivity (expected):Canine, Bovine, Mouse, Rat.
    Species reactivity (tested):Human.
    Purification
    Affinity chromatography
    Immunogen
    Synthetic peptide corresponding to amino acids surrounding T595 of Human MARK2 isoform a. The immunogen peptide was phosphorylated at the residue corresponding to T595
    Isotype
    IgG
    Top Product
    Discover our top product MARK2 Primary Antibody
  • Application Notes
    ELISA: 1/1,000 - 1/3,000. Western Blot: 1/250 - 1/1,000.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Concentration
    0.6 mg/mL (by UV absorbance at 280 nm)
    Buffer
    0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2 containing 0.01 % (w/v) Sodium Azide
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    -20 °C
  • Target
    MARK2 (MAP/microtubule Affinity-Regulating Kinase 2 (MARK2))
    Alternative Name
    MARK2 (MARK2 Products)
    Synonyms
    EMK-1 antibody, EMK1 antibody, PAR-1 antibody, Par-1b antibody, Par1b antibody, AU024026 antibody, Emk antibody, Par-1 antibody, mKIAA4207 antibody, microtubule affinity regulating kinase 2 antibody, MAP/microtubule affinity regulating kinase 2 antibody, MARK2 antibody, Mark2 antibody
    Background
    This antibody recognizes a regulatory phosphorylation on a kinase that is critical to regulation of microtubules, cell cycle and immune responses. MARK2 refers to MAP/microtubule affinity-regulating kinase 2 isoform a [Homo sapiens]. EMK (ELKL Motif Kinase) is a small family of ser/thr protein kinases involved in the control of cell polarity, microtubule stability and cancer. Several cDNA clones have been isolated that encode two isoforms of the human ser/thr protein kinase EMK1 called MARK2. These isoforms were characterized by the presence of a 162-bp alternative exon that gives rise to two forms, one containing the exon and the other one lacking it. Both forms were found to be co-expressed in a number of selected cell lines and tissue samples. Human MARK2 was shown to be encoded by a single mRNA that is ubiquitously expressed. This transcription variant includes the alternative exon in the coding region and therefore codes for a longer protein. Multiple splice variants exist for this protein.Synonyms: 2, ELKL motif kinase, EMK1, MAP/microtubule affinity-regulating kinase, MARK2, PAR1 homolog, Serine/threonine-protein kinase
    Gene ID
    2011
    NCBI Accession
    NP_001034558
    UniProt
    Q7KZI7
    Pathways
    SARS-CoV-2 Protein Interactome, The Global Phosphorylation Landscape of SARS-CoV-2 Infection
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