M-CSF/CSF1 antibody

Catalog No. ABIN452500

This Mouse Monoclonal antibody specifically detects M-CSF/CSF1 in EIA. It exhibits reactivity toward Human.

Quick Overview for M-CSF/CSF1 antibody (ABIN452500)

Target: M-CSF/CSF1 (CSF1) (Colony Stimulating Factor 1 (Macrophage) (CSF1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This M-CSF/CSF1 antibody is un-conjugated

Application: Enzyme Immunoassay (EIA)

Clone: 692

Product Details anti-M-CSF/CSF1 Antibody

Specificity: This monoclonal antibody is specifically reactive to rhM-CSF. Does not cross react with BSA or other Human cytokines tested such as IL1 beta, IL-8, IL-16, EGF, G-CSFR, GM-CSF, MCP-1, MCP-3, TGF beta and TNF alpha.

Cross-Reactivity (Details): Species reactivity (tested):Human.

Characteristics: Synonyms: CSF-1, CSF1, MCSF, Macrophage colony-stimulating factor 1

Purification: Affinity Chromatography on Protein G.

Immunogen: Purified recombinant Human M-CSF (rhM-CSF)

Isotype: IgG2a

Application Details

Application Notes: ELISA.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Reconstitution: Restore with Double distillated water to adjust the final concentration to 1.00 mg/mL

Buffer: 0.01 M PBS, pH 7.2 without preservatives.

Preservative: Without preservative

Storage: -20 °C

Storage Comment: Store the antibody (in aliquots) at -20 °C. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.

Expiry Date: 12 months

Target Details for M-CSF/CSF1

Target: M-CSF/CSF1 (CSF1) (Colony Stimulating Factor 1 (Macrophage) (CSF1))

Alternative Name: Macrophage Colony Stimulating Factor (M-CSF)

Background: Four distinct colony-stimulating factors (CSFs) that promote survival, proliferation and differentiation of bone marrow precursor cells have been well characterized: granulocyte macrophage CSF (GMCSF), granulocyte CSF (GCSF), macrophage CSF (MCSF), and Interleukin-3 (IL-3, Multi CSF). Both GMCSF and IL-3 are multipotential growth factors, stimulating proliferation of progenitor cells from more than one hematopoietic lineage. In contrast, GCSF and MCSF are lineage restricted hematopoietic growth factors, stimulating final mitotic divisions and the terminal cellular maturation of the partially differentiated hematopoietic progenitors. Macrophage CSF, also known as CSF1, is produced by monocytes, fibroblasts and endothelial cells. It stimulates the formation of macrophage colonies, enhances antibody-dependent, cell-mediated cytotoxicity by monocytes and macrophages, and inhibits bone resorption by osetoclasts. Natural human MCSF is a dimeric glycoprotein of 70-90 kD molecular weight, existing in multiple glycosylation forms. It binds to a 165 kD glycoprotein of the receptor tyrosine kinase subclass III, a family that includes the receptors for platelet derived growth factor (PDGF) and stem cell factor (SCF).Synonyms: CSF-1, CSF1, MCSF, Macrophage colony-stimulating factor 1

Gene ID: 1435

UniProt: P09603

Pathways: RTK Signaling