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ASPSCR1 antibody (C-Term)

ASPSCR1 Reactivity: Human WB, EIA Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN453522
  • Target See all ASPSCR1 Antibodies
    ASPSCR1 (Alveolar Soft Part Sarcoma Chromosome Region, Candidate 1 (ASPSCR1))
    Binding Specificity
    • 15
    • 9
    • 9
    • 9
    • 8
    • 7
    • 7
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reactivity
    • 52
    • 21
    • 15
    • 5
    • 4
    • 2
    • 1
    Human
    Host
    • 73
    • 7
    Rabbit
    Clonality
    • 73
    • 8
    Polyclonal
    Conjugate
    • 33
    • 8
    • 8
    • 7
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    This ASPSCR1 antibody is un-conjugated
    Application
    • 62
    • 43
    • 13
    • 13
    • 6
    • 5
    • 4
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    Western Blotting (WB), Enzyme Immunoassay (EIA)
    Specificity
    This antibody is specific to ASPSCR1/TUG (C-term).
    Cross-Reactivity (Details)
    Species reactivity (tested):Human.
    Purification
    Protein A Chromatography followed by peptide affinity purification.
    Immunogen
    KLH conjugated synthetic peptide selected from the C-terminal region of Human ASPSCR1.
    Top Product
    Discover our top product ASPSCR1 Primary Antibody
  • Application Notes
    ELISA: 1/1,000. Western blot: 1/100approx. 1/500.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    0.25 mg/mL
    Buffer
    PBS containing 0.09 % (W/V) Sodium Azide as preservative.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    4 °C/-20 °C
    Storage Comment
    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • Target
    ASPSCR1 (Alveolar Soft Part Sarcoma Chromosome Region, Candidate 1 (ASPSCR1))
    Alternative Name
    ASPSCR1 (ASPSCR1 Products)
    Synonyms
    tug antibody, aspl antibody, asps antibody, rcc17 antibody, ubxd9 antibody, aspcr1 antibody, ASPCR1 antibody, ASPL antibody, ASPS antibody, RCC17 antibody, TUG antibody, UBXD9 antibody, UBXN9 antibody, 1190006K01Rik antibody, ASPC antibody, ASPSCR1, UBX domain containing tether for SLC2A4 antibody, alveolar soft part sarcoma chromosome region, candidate 1 S homeolog antibody, alveolar soft part sarcoma chromosome region, candidate 1 antibody, alveolar soft part sarcoma chromosome region, candidate 1 (human) antibody, ASPSCR1 antibody, aspscr1.S antibody, Aspscr1 antibody, aspscr1 antibody, Bm1_55980 antibody
    Background
    ASPSCR1 is tethering protein that sequesters GLUT4-containing vesicles in the cytoplasm in the absence of insulin. Modulates the amount of GLUT4 that is available at the cell surface. Insulin stimulates glucose uptake in fat and muscle by mobilizing the GLUT4 glucose transporter. GLUT4 is sequestered intracellularly in the absence of insulin, and is redistributed to the plasma membrane within minutes of insulin stimulation. Bogan et al. (2003) described a functional screen to identify proteins that modulate GLUT4 distribution, and identified TUG as a putative tether, containing a UBX domain, for GLUT4. They identified the ASPL protein as the probable human homolog of murine TUG. In truncated form, TUG acts in a dominant-negative manner to inhibit insulin-stimulated GLUT4 redistribution in Chinese hamster ovary cells and 3T3-L1 adipocytes. Full-length TUG forms a complex specifically with GLUT4, in 3T3-L1 adipocytes, this complex is present in unstimulated cells and is largely disassembled by insulin. Endogenous TUG is localized with the insulin-mobilizable pool of GLUT4 in unstimulated 3T3-L1 adipocytes, and is not mobilized to the plasma membrane by insulin. Distinct regions of TUG are required to bind GLUT4 and to retain GLUT4 intracellularly in transfected, nonadipose cells. Bogan et al. (2003) concluded that TUG traps endocytosed GLUT4 and tethers it intracellularly, and that insulin mobilizes this pool of retained GLUT4 by releasing this tether. Bogan et al. (2003) found that TUG exists in 2 isoforms, the longer of which contains a sequence at the amino terminus with similarity to ubiquitin that is predicted to be 550 residues long. The probable start codon in the short form is equivalent to methionine-78 of the long form.Synonyms: ASPL, Alveolar soft part sarcoma chromosomal region candidate gene 1 protein, Alveolar soft part sarcoma locus, RCC17, Renal papillary cell carcinoma protein 17, TUG, Tether containing UBX domain for GLUT4, UBX domain-containing protein 9, UBXD9, UBXN9
    Gene ID
    79058
    NCBI Accession
    NP_076988
    UniProt
    Q9BZE9
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