VCAM1 antibody (APC)

Catalog No. ABIN457311

Cited in 2+ publications. The APC-conjugated Mouse Monoclonal anti-VCAM1 antibody (Clone STA) (ABIN457311) specifically detects VCAM1 in FACS. The antibody is reactive with Human samples.

Quick Overview for VCAM1 antibody (APC) (ABIN457311)

Target: VCAM1 (Vascular Cell Adhesion Molecule 1 (VCAM1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This VCAM1 antibody is conjugated to APC

Application: Flow Cytometry (FACS)

Clone: STA

Product Details anti-VCAM1 Antibody (APC)

Purpose: Anti-Hu CD106 APC

Cross-Reactivity (Details): Human

Characteristics: The mouse monoclonal antibody STA recognizes an extracellular epitope of CD106 antigen (VCAM-1), a 100-110 kDa type I membrane protein of the immunoglobulin superfamily, a crucial mediator of leukocyte adhesion, and a costimulation molecule.

Purification: Purified antibody is conjugated with activated allophycocyanin (APC) under optimum conditions and unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.

Immunogen: Human DS6 T cell line

Isotype: IgG1

Application Details

Application Notes: Flow cytometry: The reagent is designed for analysis of human blood cells using 10 μL reagent / 100 μL of whole blood or 10⁶ cells in a suspension. The content of a vial (1 ml) is sufficient for 100 tests.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Do not freeze,Protect from prolonged exposure to light

Storage: 4 °C

Storage Comment: Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.

References for anti-VCAM1 antibody (APC) (ABIN457311)

Yen, Liao, Hsiao, Kao, Chen, Wu-Hsieh: "Modeling the early events of severe acute respiratory syndrome coronavirus infection in vitro." in: Journal of virology, Vol. 80, Issue 6, pp. 2684-93, (2006) (PubMed).

Leca, Mansur, Bensussan: "Expression of VCAM-1 (CD106) by a subset of TCR gamma delta-bearing lymphocyte clones. Involvement of a metalloprotease in the specific hydrolytic release of the soluble isoform." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 154, Issue 3, pp. 1069-77, (1995) (PubMed).

Target Details for VCAM1

Target: VCAM1 (Vascular Cell Adhesion Molecule 1 (VCAM1))

Alternative Name: CD106

Background: Vascular cell adhesion molecule 1,CD106 / VCAM-1 (vascular cell adhesion molecule-1) is an Ig-like cell surface adhesion molecule binding VLA-4 integrin. VCAM-1 is a potent T cell costimulatory molecule taking part in their positive selection and survival, as well as in adhesion, transendothelial migration and activation of peripheral T cells. VCAM-1 is also involved in endothelial cell-cell contacts. Whereas VCAM-1 normally mediates leukocyte extravasion to sites of tissue inflammation, tumour cells can use overexpressed VCAM-1 to escape T cell immunity. Soluble form of VCAM-1 (sVCAM-1) is an inflammatory marker and can be used also in prognosis of subsequent cariovascular events following acute coronary syndromes.,VCAM-1, INCAM-100

Gene ID: 7412

UniProt: P19320

Pathways: Carbohydrate Homeostasis