LTB antibody (AA 181-230)

Catalog No. ABIN484458

The Rabbit Polyclonal anti-LTB antibody (ABIN484458) specifically detects LTB in WB, ELISA and IF. The antibody is reactive with Human and Mouse samples.

Quick Overview for LTB antibody (AA 181-230) (ABIN484458)

Target: LTB (Lymphotoxin beta (TNF Superfamily, Member 3) (LTB))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This LTB antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF)

Product Details anti-LTB Antibody

Binding Specificity: AA 181-230

Purpose: LT-β Antibody

Specificity: LT-β Polyclonal Antibody detects endogenous levels of LT-β protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Purity: > 95 %

Immunogen: The antiserum was produced against synthesized peptide derived from human TNFC. AA range:181-230

Isotype: IgG

Application Details

Application Notes: WB 1:500 - 1:2000. IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C/1 year

Expiry Date: 12 months

Target Details for LTB

Target: LTB (Lymphotoxin beta (TNF Superfamily, Member 3) (LTB))

Alternative Name: TNFC

Background:

Synonyms: LTB, TNFC, TNFSF3, Lymphotoxin-beta, LT-beta, Tumor necrosis factor C, TNF-C, Tumor necrosis factor ligand superfamily member 3

Background: Lymphotoxin beta is a type II membrane protein of the TNF family. It anchors lymphotoxin-alpha to the cell surface through heterotrimer formation. The predominant form on the lymphocyte surface is the lymphotoxin-alpha 1/beta 2 complex (e.g. 1 Molecule alpha/2 Molecules beta) and this complex is the primary ligand for the lymphotoxin-beta receptor. The minor complex is lymphotoxin-alpha 2/beta 1. LTB is an inducer of the inflammatory response system and involved in normal development of lymphoid tissue. Lymphotoxin-beta isoform b is unable to complex with lymphotoxin-alpha suggesting a function for lymphotoxin-beta which is independent of lympyhotoxin-alpha. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008],

Gene Name: LTB

Protein Name: Lymphotoxin-beta

Molecular Weight: 25 kDa

Gene ID: 4050

OMIM: 600978

UniProt: Q06643

Pathways: NF-kappaB Signaling