FBXW7 antibody (HRP)

Catalog No. ABIN4880105

This anti-FBXW7 antibody is a Mouse Monoclonal antibody detecting FBXW7 in . Suitable for Human and Mouse.

Quick Overview for FBXW7 antibody (HRP) (ABIN4880105)

Target: FBXW7 (F-Box and WD Repeat Domain Containing 7 (FBXW7))

Reactivity: Human, Mouse

Host: Mouse

Clonality: Monoclonal

Conjugate: This FBXW7 antibody is conjugated to HRP

Application: Please inquire

Clone: FBOX 3a9-1

Product Details anti-FBXW7 Antibody (HRP)

Specificity: This antibody recognises F-box/WD repeat-containing protein 7 (Fbxw7), which is also known as cdc4 and SEL-10. The FBW7/Cdc4 F-box protein was first recognized by its ability to bind cyclin E and the SCF (FBW7) is now known to target c-Myc, c-Jun and Notch for degradation in addition to its role in cyclin E proteolysis. FBW7 negatively regulates several key oncoproteins and is a tumour suppressor that is mutated in a wide spectrum of human cancers.

Purification: Purified on protein A from tissue culture supernatant.

Immunogen: Synthetic peptide of human sequence

Isotype: IgG1

Application Details

Application Notes: Optimal antibody dilution should be determined by titration

Comment:

Myeloma, fusion partnersCells from immunized mice were fused with the Sp2/0-Ag.14 myeloma cell line

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Purified IgG conjugated to Horseradish Peroxidase using Innova Biosciences Lightning-Link ®, supplied in Phosphate buffered saline (PBS) containing 0.01 % Thiomersal

Preservative: Thimerosal (Merthiolate)

Precaution of Use: This product contains Thimerosal (Merthiolate) a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Target Details for FBXW7

Target: FBXW7 (F-Box and WD Repeat Domain Containing 7 (FBXW7))

Alternative Name: Fbxw7/Cdc4

Gene ID: 55294, 50754

OMIM: 606278

Pathways: Notch Signaling, EGFR Signaling Pathway