Retinoblastoma 1 antibody (HRP)

Catalog No. ABIN4880121

Product Details anti-Retinoblastoma 1 Antibody (HRP)

Target: Retinoblastoma 1 (RB1)

Reactivity: Human, Mouse

Host: Mouse

Clonality: Monoclonal

Conjugate: This Retinoblastoma 1 antibody is conjugated to HRP

Application: Please inquire

Specificity: This antibody recognises retinoblastoma-associated protein (RB), a 105 kDa tumour suppressor which is also known as Rb1. Rb1 functions as a transcription factor that controls cell cycle progression (at the G1/S phase transition) through its repression of E2F-mediated transcription. Mutation of the Rb gene is found frequently in human sarcomas, lung, bladder and breast carcinomas and is the molecular basis for hereditary disposition to retinoblastoma.

Purification: Purified on protein A from tissue culture supernatant.

Immunogen: Rb-b-galactosidase fusion protein spanning nucleotides 1126-1973 of human Rb gel purified from bacterial lysates

Clone: 1F8

Isotype: IgG1

Application Details

Application Notes: Optimal antibody dilution should be determined by titration

Comment:

Myeloma, fusion partnersCells from immunized Balb/c mice were fused with the Sp2/0-Ag.14 myeloma cell line

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Purified IgG conjugated to Horseradish Peroxidase using Innova Biosciences Lightning-Link ®, supplied in Phosphate buffered saline (PBS) containing 0.01 % Thiomersal

Preservative: Thimerosal (Merthiolate)

Precaution of Use: This product contains Thimerosal (Merthiolate) a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Target Details for Retinoblastoma 1

Target: Retinoblastoma 1 (RB1)

Alternative Name: Rb1 (RB1 Products)

Gene ID: 5925, 19645

OMIM: 614041

Pathways: Cell Division Cycle, Intracellular Steroid Hormone Receptor Signaling Pathway, Mitotic G1-G1/S Phases, DNA Replication, Maintenance of Protein Location, Synthesis of DNA, Autophagy