FGG antibody (N-Term)

Catalog No. ABIN4886589

Product Details anti-FGG Antibody

Target: FGG (Fibrinogen gamma Chain (FGG))

Binding Specificity: AA 133-163, N-Term

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FGG antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purpose: Rabbit IgG polyclonal antibody for Fibrinogen gamma chain(FGG) detection. Tested with WB, IHC-P in Human,Mouse,Rat.

Sequence: IRYLQEIYNS NNQKIVNLKE KVAQLEAQCQ E

Cross-Reactivity (Details): No cross reactivity with other proteins.

Characteristics: Rabbit IgG polyclonal antibody for Fibrinogen gamma chain(FGG) detection. Tested with WB, IHC-P in Human,Mouse,Rat.
Gene Name: fibrinogen gamma chain
Protein Name: Fibrinogen gamma chain

Purification: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the N-terminus of human FGG (133-163aa IRYLQEIYNSNNQKIVNLKEKVAQLEAQCQE), different from the related mouse sequence by two amino acids, and from the related rat sequence by five amino acids.

Isotype: IgG

Application Details

Application Notes: WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, Mouse, Rat
IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Human, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
Notes: Tested Species: Species with positive results. Other applications have not been tested. Optimal dilutions should be determined by end users.

Comment:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

Target Details for FGG

Target: FGG (Fibrinogen gamma Chain (FGG))

Alternative Name: FGG (FGG Products)

Synonyms: FXII antibody, HAF antibody, 3010002H13Rik antibody, AI256424 antibody, fibrinogen antibody, FGG antibody, LOC100220680 antibody, fb60h05 antibody, fb62e01 antibody, wu:fb60h05 antibody, wu:fb62e01 antibody, zgc:56023 antibody, fibrinogen gamma chain antibody, coagulation factor XII (Hageman factor) antibody, fibrinogen gamma chain L homeolog antibody, FGG antibody, F12 antibody, fgg antibody, Fgg antibody, fgg.L antibody, CpipJ_CPIJ006387 antibody, CpipJ_CPIJ010087 antibody

Background: Fibrinogen gamma chain, also known as FGG, is a human gene found on Chromosome 4. The protein encoded by this gene is the gamma component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including dysfibrinogenemia, hypofibrinogenemia and thrombophilia. Alternative splicing results in transcript variants encoding different isoforms.

Synonyms: FGG | Fibrinogen gamma chain | Fibrinogen gamma polypeptide | fibrinogen gamma-b chain | P02679

Gene ID: 2266

UniProt: P02679