IL12RB1 antibody (C-Term)

Catalog No. ABIN4886631

Product Details anti-IL12RB1 Antibody

Target: IL12RB1 (Interleukin 12 Receptor beta 1 (IL12RB1))

Binding Specificity: AA 624-662, C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IL12RB1 antibody is un-conjugated

Application: Western Blotting (WB)

Purpose: Rabbit IgG polyclonal antibody for Interleukin-12 receptor subunit beta-1 (IL12RB1) detection. Tested with WB in Human.

Sequence: DKGERTEPLE KTELPEGAPE LALDTELSLE DGDRCKAKM

Cross-Reactivity (Details): No cross reactivity with other proteins.

Characteristics: Rabbit IgG polyclonal antibody for Interleukin-12 receptor subunit beta-1 (IL12RB1) detection. Tested with WB in Human.
Gene Name: interleukin 12 receptor subunit beta 1
Protein Name: Interleukin-12 receptor subunit beta-1

Purification: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human IL12RB1 (624-662aa DKGERTEPLEKTELPEGAPELALDTELSLEDGDRCKAKM).

Isotype: IgG

Application Details

Application Notes: WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human
Notes: Tested Species: Species with positive results.
Other applications have not been tested. Optimal dilutions should be determined by end users.

Comment:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

Target Details for IL12RB1

Target: IL12RB1 (Interleukin 12 Receptor beta 1 (IL12RB1))

Alternative Name: IL12RB1 (IL12RB1 Products)

Synonyms: Il12rb antibody, IL12RB1 antibody, IL-12R antibody, CD212 antibody, IL-12R-BETA1 antibody, IL12RB antibody, IL-12R[b] antibody, interleukin 12 receptor subunit beta 1 antibody, interleukin 12 receptor, beta 1 antibody, Il12rb1 antibody, IL12RB1 antibody

Background: IL12RB1, mapped to 19p13.11, is also known as CD212. The protein encoded by this gene is a type I transmembrane protein that belongs to the hemopoietin receptor superfamily. This protein binds to interleukine 12 (IL12) with a low affinity, and is thought to be a part of IL12 receptor complex. And this protein forms a disulfide-linked oligomer, which is required for its IL12 binding activity. The coexpression of this and IL12RB2 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. Mutations in this gene impair the development of interleukin-17-producing T lymphocytes and result in increased susceptibility to mycobacterial and Salmonella infections. Alternative splicing results in multiple transcript variants.

Synonyms: CD212 | IL-12R-beta-1 | IL-12RB1 | IL12RB | Il12rb1 | IMD3 | IMD30 | P42701

Gene ID: 3594

UniProt: P42701

Pathways: JAK-STAT Signaling, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Activated T Cell Proliferation