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MAP3K7 antibody (C-Term)

MAP3K7 Reactivity: Human, Rat WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN4886662
  • Target See all MAP3K7 Antibodies
    MAP3K7 (Mitogen-Activated Protein Kinase Kinase Kinase 7 (MAP3K7))
    Binding Specificity
    • 18
    • 10
    • 9
    • 8
    • 8
    • 7
    • 7
    • 6
    • 5
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 566-603, C-Term
    Reactivity
    • 108
    • 40
    • 27
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Rat
    Host
    • 102
    • 6
    • 1
    Rabbit
    Clonality
    • 99
    • 10
    Polyclonal
    Conjugate
    • 68
    • 8
    • 8
    • 7
    • 6
    • 6
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This MAP3K7 antibody is un-conjugated
    Application
    • 85
    • 65
    • 46
    • 16
    • 10
    • 8
    • 5
    • 5
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Purpose
    Rabbit IgG polyclonal antibody for Mitogen-activated protein kinase kinase kinase 7(MAP3K7) detection. Tested with WB in Human,Rat.
    Sequence
    RLVQEHKKLL DENKSLSTYY QQCKKQLEVI RSQQQKRQ
    Cross-Reactivity (Details)
    No cross reactivity with other proteins.
    Characteristics
    Rabbit IgG polyclonal antibody for Mitogen-activated protein kinase kinase kinase 7(MAP3K7) detection. Tested with WB in Human,Rat.
    Gene Name: mitogen-activated protein kinase kinase kinase 7
    Protein Name: Mitogen-activated protein kinase kinase kinase 7
    Purification
    Immunogen affinity purified.
    Immunogen
    A synthetic peptide corresponding to a sequence at the C-terminus of human TAK1 (566-603aa RLVQEHKKLLDENKSLSTYYQQCKKQLEVIRSQQQKRQ), identical to the related mouse and rat sequences.
    Isotype
    IgG
    Top Product
    Discover our top product MAP3K7 Primary Antibody
  • Application Notes
    WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, Rat
    Notes: Tested Species: Species with positive results.
    Other applications have not been tested. Optimal dilutions should be determined by end users.
    Comment

    Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
    Concentration
    500 μg/mL
    Buffer
    Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    4 °C/-20 °C
    Storage Comment
    At -20°C for one year. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.
  • Target
    MAP3K7 (Mitogen-Activated Protein Kinase Kinase Kinase 7 (MAP3K7))
    Alternative Name
    MAP3K7 (MAP3K7 Products)
    Synonyms
    si:ch211-225h9.1 antibody, zgc:110612 antibody, Tak1 antibody, MEKK7 antibody, TAK1 antibody, TGF1a antibody, B430101B05 antibody, C87327 antibody, mitogen-activated protein kinase kinase kinase 7 antibody, mitogen activated protein kinase kinase kinase 7 antibody, map3k7 antibody, Map3k7 antibody, MAP3K7 antibody
    Background
    Mitogen-activated protein kinase kinase kinase 7, also known as TAK1, is an enzyme that in humans is encoded by the MAP3K7 gene. The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase mediates the signaling transduction induced by TGF beta and morphogenetic protein (BMP), and controls a variety of cell functions including transcription regulation and apoptosis. In response to IL-1, this protein forms a kinase complex including TRAF6, MAP3K7P1/TAB1 and MAP3K7P2/TAB2, this complex is required for the activation of nuclear factor kappa B. This kinase can also activate MAPK8/JNK, MAP2K4/MKK4, and thus plays a role in the cell response to environmental stresses. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.

    Synonyms: MAP3K 7 | MAP3K7 | MEKK7 | TAK1 | TGF1a | O43318
    Gene ID
    6885
    UniProt
    O43318
    Pathways
    NF-kappaB Signaling, TCR Signaling, TLR Signaling, Fc-epsilon Receptor Signaling Pathway, Activation of Innate immune Response, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Tube Formation, Toll-Like Receptors Cascades, BCR Signaling, Ubiquitin Proteasome Pathway
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