L3MBTL2 antibody (AA 1-230)

Catalog No. ABIN4889662

There is 1 publication for this product available. The Rabbit Polyclonal anti-L3MBTL2 antibody is suitable to detect L3MBTL2 in samples from Human. It has been validated for WB and IP.

Quick Overview for L3MBTL2 antibody (AA 1-230) (ABIN4889662)

Target: L3MBTL2 (Lethal(3) Malignant Brain Tumor-Like Protein 2 (L3MBTL2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This L3MBTL2 antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP)

Product Details anti-L3MBTL2 Antibody

Binding Specificity: AA 1-230

Purpose: L3MBTL2 antibody (pAb)

Purification: Unpurified

Immunogen: This L3MBTL2 antibody was raised against a His-Tagged fusion protein containing amino acids 1-230 of human L3MBTL2.

Application Details

Application Notes: IP: 10 µL per IP WB: 1:500 - 1:2,000 dilution

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Rabbit serum containing 30 % glycerol and 0.035 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions,Keep all reagents on ice when not in storage

Storage: -20 °C

Storage Comment: Some products may be shipped at room temperature. This will not affect their stability or performance. Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.

Expiry Date: 24 months

References for anti-L3MBTL2 antibody (ABIN4889662)

LaFave, Béguelin, Koche, Teater, Spitzer, Chramiec, Papalexi, Keller, Hricik, Konstantinoff, Micol, Durham, Knutson, Campbell, Blum, Shi, Doud, Krivtsov, Chung, Khodos, de Stanchina, Ouerfelli et al.: "Loss of BAP1 function leads to EZH2-dependent transformation. ..." in: Nature medicine, Vol. 21, Issue 11, pp. 1344-9, (2015) (PubMed).

Target Details for L3MBTL2

Target: L3MBTL2 (Lethal(3) Malignant Brain Tumor-Like Protein 2 (L3MBTL2))

Alternative Name: L3MBTL2

Background: L3MBTL2 (Lethal (3) malignant brain tumor-like 2 protein) is a putative member of the polycomb group family and is the human homolog of Drosophila Sfmbt, critical for Hox gene silencing. L3MBTL2 contains one FCS-type zinc finger and four MBT (malignant brain tumor) repeats. L3MBTL2 associates with chromatin-remodeling complexes and helps inhibit the expression of proteins that trigger the cells into mitosis. L3MBTL2 is a part of a complex involved in the G0 phase of the cell cycle. This complex contains other proteins such as E2F-6, Max or HP1 gamma, and participates in transcriptional repression.

Molecular Weight: 90 kDa

Gene ID: 83746

NCBI Accession: NP_113676