APP antibody

Catalog No. ABIN4901000

The Mouse Monoclonal anti-APP antibody has been validated for WB, ELISA and IHC (p). It is suitable to detect APP in samples from Human.

Quick Overview for APP antibody (ABIN4901000)

Target: APP (Amyloid beta (A4) Precursor Protein (APP))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This APP antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: 1B11F3

Product Details anti-APP Antibody

Purpose: Mouse monoclonal to APP.

Specificity: APP Monoclonal Antibody detects endogenous levels of APP protein.

Characteristics: Mouse Monoclonal to APP.

Purification: Affinity purification

Immunogen: Purified recombinant fragment of APP expressed in E. Coli.

Isotype: IgG2a

Application Details

Application Notes: WB 1:500-1:2000
IHC 1:200-1:1000
ELISA 1:10000

Comment:

Expressed in all fetal tissues examined with highest levels in brain, kidney, heart and spleen. Weak expression in liver. In adult brain, highest expression found in the frontal lobe of the cortex and in the anterior perisylvian cortex-opercular gyri. Moderate expression in the cerebellar cortex, the posterior perisylvian cortex-opercular gyri and the temporal associated cortex. Weak expression found in the striate, extra-striate and motor cortices. Expressed in cerebrospinal fluid, and plasma. Isoform APP695 is the predominant form in neuronal tissue, isoform APP751 and isoform APP770 are widely expressed in non-neuronal cells. Isoform APP751 is the most abundant form in T-lymphocytes. Appican is expressed in astrocytes.

Restrictions: For Research Use only

Handling

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze/thaw cycles.

Storage: -20 °C

Storage Comment: Store at -20°C, and avoid repeat freeze-thaw cycles.

Target Details for APP

Target: APP (Amyloid beta (A4) Precursor Protein (APP))

Alternative Name: APP

Gene ID: 351

UniProt: P05067

Pathways: Caspase Cascade in Apoptosis, EGFR Signaling Pathway, Transition Metal Ion Homeostasis, Skeletal Muscle Fiber Development, Toll-Like Receptors Cascades, Feeding Behaviour