SORL1 antibody

Catalog No. ABIN4902295

This Mouse Monoclonal antibody specifically detects SORL1 in WB, ELISA, IF and IHC (p). It exhibits reactivity toward Human.

Quick Overview for SORL1 antibody (ABIN4902295)

Target: SORL1 (Sortilin-Related Receptor, L(DLR Class) A Repeats Containing (SORL1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This SORL1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: 3B6B11

Product Details anti-SORL1 Antibody

Purpose: Mouse monoclonal to SorLA.

Specificity: SorLA Monoclonal Antibody detects endogenous levels of SorLA protein.

Characteristics: Mouse Monoclonal to SorLA.

Purification: Affinity purification

Immunogen: Purified recombinant fragment of human SorLA expressed in E. Coli.

Isotype: IgG1

Application Details

Application Notes: WB 1:500-1:2000
IHC 1:200-1:1000
IF 1:200-1:1000
ELISA 1:10000

Comment:

Expressed mainly in brain, where it is most abundant in the cerebellum, cerebral cortex and the occipital pole, low expression in the putamen and the thalamus. Expression is significantly reduced in the frontal cortex of patients suffering from Alzheimer disease. According to PubMed:9157966, found in spinal cord, testis, liver, kidney and pancreas with detectable levels in placenta, lung and heart. According to PubMed:8940146, expressed in the prostate, ovary, thyroid and spleen, but not found in kidney, liver, lung, skeletal muscle, bone marrow and adrenals.

Restrictions: For Research Use only

Handling

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze/thaw cycles.

Storage: -20 °C

Storage Comment: Store at -20°C, and avoid repeat freeze-thaw cycles.

Target Details for SORL1

Target: SORL1 (Sortilin-Related Receptor, L(DLR Class) A Repeats Containing (SORL1))

Alternative Name: SorLA

Gene ID: 6653

UniProt: Q92673

Pathways: Smooth Muscle Cell Migration