TOR1A antibody

Catalog No. ABIN4908959

The Mouse Monoclonal anti-TOR1A antibody has been validated for WB. It is suitable to detect TOR1A in samples from Human.

Quick Overview for TOR1A antibody (ABIN4908959)

Target: TOR1A (Torsin Family 1, Member A (Torsin A) (TOR1A))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This TOR1A antibody is un-conjugated

Application: Western Blotting (WB)

Clone: 3C3

Product Details anti-TOR1A Antibody

Cross-Reactivity: Human

Purification: Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.

Immunogen: Purified His-tagged DYT1 protein(Fragment) was used to produced this monoclonal antibody.

Isotype: IgG1

Application Details

Application Notes: WB 1:300-5000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for TOR1A

Target: TOR1A (Torsin Family 1, Member A (Torsin A) (TOR1A))

Alternative Name: DYT1

Background:

Synonyms: DQ2, DYT1, Torsin-1A, Dystonia 1 protein, Torsin ATPase-1A, Torsin family 1 member A, TOR1A, TA, TORA

Background: Protein with chaperone functions important for the control of protein folding, processing, stability and localization as well as for the reduction of misfolded protein aggregates. Involved in the regulation of synaptic vesicle recycling, controls STON2 protein stability in collaboration with the COP9 signalosome complex (CSN). In the nucleus, may link the cytoskeleton with the nuclear envelope, this mechanism seems to be crucial for the control of nuclear polarity, cell movement and, specifically in neurons, nuclear envelope integrity. Participates in the cellular trafficking and may regulate the subcellular location of multipass membrane proteins such as the dopamine transporter SLC6A3, leading to the modulation of dopamine neurotransmission. In the endoplasmic reticulum, plays a role in the quality control of protein folding by increasing clearance of misfolded proteins such as SGCE variants or holding them in an intermediate state for proper refolding. May have a redundant function with TOR1B in non-neural tissues.

Gene ID: 1861

UniProt: O14656

Pathways: SARS-CoV-2 Protein Interactome