RYK antibody

Catalog No. ABIN4913824

This Mouse Monoclonal antibody specifically detects RYK in WB and FACS. It exhibits reactivity toward Human.

Quick Overview for RYK antibody (ABIN4913824)

Target: RYK (RYK Receptor-Like Tyrosine Kinase (RYK))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This RYK antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS)

Clone: 1C1

Product Details anti-RYK Antibody

Cross-Reactivity: Human

Purification: Purified by Protein G.

Immunogen: This RYK antibody is generated from a mouse immunized with a KLH conjugated synthetic peptide between 260-565 amino acids from human RYK.

Isotype: IgG1

Application Details

Application Notes: WB 1:300-5000
FCM 1:20-100

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for RYK

Target: RYK (RYK Receptor-Like Tyrosine Kinase (RYK))

Alternative Name: RYK

Background:

Synonyms: JTK5, RYK1, JTK5A, D3S3195, Tyrosine-protein kinase RYK, RYK

Background: May be a coreceptor along with FZD8 of Wnt proteins, such as WNT1, WNT3, WNT3A and WNT5A. Involved in neuron differentiation, axon guidance, corpus callosum establishment and neurite outgrowth. In response to WNT3 stimulation, receptor C-terminal cleavage occurs in its transmembrane region and allows the C-terminal intracellular product to translocate from the cytoplasm to the nucleus where it plays a crucial role in neuronal development.

Gene ID: 6259

UniProt: P34925

Pathways: RTK Signaling, WNT Signaling, Regulation of Cell Size