SMAD1 antibody (AA 151-250) (HRP)

Catalog No. ABIN4914142

This Rabbit Polyclonal antibody specifically detects SMAD1 in WB, IHC (p) and IHC (fro). It exhibits reactivity toward Human.

Quick Overview for SMAD1 antibody (AA 151-250) (HRP) (ABIN4914142)

Target: SMAD1 (SMAD, Mothers Against DPP Homolog 1 (SMAD1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SMAD1 antibody is conjugated to HRP

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-SMAD1 Antibody (HRP)

Binding Specificity: AA 151-250

Purpose: SMAD1 Polyclonal Antibody, HRP Conjugated

Specificity: This antibody may cross react with AKAP6 due to a few animo acid sequence similarity.

Cross-Reactivity: Human, Mouse, Rat

Predicted Reactivity: Chicken

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human SMAD1

Isotype: IgG

Application Details

Application Notes: WB(1:300-5000),

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for SMAD1

Target: SMAD1 (SMAD, Mothers Against DPP Homolog 1 (SMAD1))

Alternative Name: SMAD1

Background:

Synonyms: BSP1, JV41, BSP-1, JV4-1, MADH1, MADR1, Mothers against decapentaplegic homolog 1, MAD homolog 1, Mothers against DPP homolog 1, Mad-related protein 1, SMAD family member 1, SMAD 1, Smad1, hSMAD1, Transforming growth factor-beta-signaling protein 1

Background: Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD1 is a receptor-regulated SMAD (R-SMAD). SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1. May act synergistically with SMAD4 and YY1 in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression.

Gene ID: 4086

UniProt: Q15797

Pathways: Stem Cell Maintenance, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development