HAX1 antibody (N-Term)

Catalog No. ABIN492528

This anti-HAX1 antibody is a Mouse Monoclonal antibody detecting HAX1 in WB and EIA. Suitable for Human, Mouse and Rat.

Quick Overview for HAX1 antibody (N-Term) (ABIN492528)

Target: HAX1 (HCLS1 Associated Protein X-1 (HAX1))

Reactivity: Human, Mouse, Rat

Host: Mouse

Clonality: Monoclonal

Conjugate: This HAX1 antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Clone: 8F9G7

Product Details anti-HAX1 Antibody

Binding Specificity: N-Term

Specificity: This antibody is expected to recognize the longest isoform (Hax1a) as well as the shortest.

Characteristics: Synonyms: HAX-1, HS1BP1, HCLS1-associated protein X-1, HS1-associating protein X-1, HS1-bindingprotein 1

Purification: Immunoaffinity Chromotography.

Immunogen: A 15 amino acid peptide near the amino terminus of Human Hax1a (GenBank accession no. NP_006109).

Isotype: IgG

Application Details

Application Notes: ELISA. Western Blot: Hax1a antibody can be used for detection of Hax1a at 1-2 μg/mL. Positive Control: Human brain tissue lysate.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Buffer: PBS containing 0.02 % Sodium Azide as preservative.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store the antibody undiluted at 2-8 °C.
Shelf life: one year from despatch.

Expiry Date: 12 months

Target Details for HAX1

Target: HAX1 (HCLS1 Associated Protein X-1 (HAX1))

Alternative Name: HAX1

Background: The HS-1 associated protein X-1 (Hax1) was initially identified in a yeast two-hybrid assay on the basis of its ability to bind to the hemapoietic cell-specific protein 1 (HS-1). Hax1 possesses anti-apoptotic activity and is structurally related to Bcl-2 family members, including the presence of BH1- and BH2-like domains. It has recently been shown to interact with HIV viral protein R (Vpr), a protein required for viral pathogenesis of HIV and linked to T-cell apoptosis through activation of caspases 3 and 9. Other studies indicate that Hax1-mediated processing of HtrA2 (also known as Omi) by the mitochondrial protease PARL allows survival of lymphocytes and neurons when cytokines are limiting. At least four isoforms of Hax1 are known to exist.Synonyms: HAX-1, HCLS1-associated protein X-1, HS1-associating protein X-1, HS1-binding protein 1, HS1BP1

Gene ID: 10456

UniProt: O00165

Pathways: Regulation of Actin Filament Polymerization