CD80 antibody

Catalog No. ABIN4949540

The Mouse Monoclonal anti-CD80 antibody (Clone C80-1608) (ABIN4949540) specifically detects CD80 in ELISA. The antibody is reactive with Human samples.

Quick Overview for CD80 antibody (ABIN4949540)

Target: CD80

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CD80 antibody is un-conjugated

Application: ELISA

Grade: Carrier-free

Clone: C80-1608

Product Details anti-CD80 Antibody

Purpose: CD80 Antibody / B7-1 (azide and preservative free)

Purification: Protein G affinity chromatography

Immunogen: Recombinant human protein used as the immunogen for the CD80 antibody.

Isotype: IgG1, kappa

Application Details

Application Notes: Optimal dilution of the CD80 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Preservative: Azide free

Storage: 4 °C,-20 °C

Storage Comment: Store the CD80 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Target Details for CD80

Target: CD80

Alternative Name: CD80

Background: T cell proliferation and lymphokine production are triggered by occupation of the TCR by antigen, followed by a costimulatory signal that is delivered by a ligand expressed on antigen presenting cells. The B7-related cell surface proteins CD80 (B7-1) and CD86 (B7-2) are expressed on antigen presenting cells bind the homologous T cell receptors CTLA-4 (cytotoxic T lymphocyte-associated protein-4) and CD28 and trigger costimulatory signals for optimal T cell activation. CTLA-4 shares 31 % overall amino acid identity with CD28 and it has been proposed that CD28 and CTLA-4 are functionally redundant. SLAM is a novel receptor on T cells that, when engaged, potentiates T cell expansion in a CD28-independent manner. B7, also designated BB1, is another ligand or counter receptor for CD28 and CTLA-4 that is expressed on the antigen-presenting cell.

UniProt: P33681

Pathways: TCR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Positive Regulation of Immune Effector Process, Cancer Immune Checkpoints