GP2 antibody (AA 35-179)

Catalog No. ABIN4949728

The Mouse Monoclonal anti-GP2 antibody is suitable to detect GP2 in samples from Human. It has been validated for FACS, IF and IHC (p).

Quick Overview for GP2 antibody (AA 35-179) (ABIN4949728)

Target: GP2 (Glycoprotein 2 (Zymogen Granule Membrane) (GP2))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This GP2 antibody is un-conjugated

Application: Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: GP2-1712

Product Details anti-GP2 Antibody

Binding Specificity: AA 35-179

No Cross-Reactivity: Mouse (Murine)

Purification: Protein G affinity chromatography

Immunogen: A partial human recombinant protein corresponding to amino acids 35-179 was used as the immunogen for the GP2 antibody.

Isotype: IgG2b lambda

Application Details

Application Notes: Optimal dilution of the GP2 antibody should be determined by the researcher.\. FACS: 0.5-1 μg/10e6 cells in 0.1ml,Immunofluorescence: 0.5-1 μg/mL,IHC (FFPE): 1-2 μg/mL for 30 min at RT

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Preservative: Azide free

Storage: 4 °C,-20 °C

Storage Comment: Store the GP2 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).

Target Details for GP2

Target: GP2 (Glycoprotein 2 (Zymogen Granule Membrane) (GP2))

Alternative Name: Glycoprotein 2 / GP2 / ZAP75

Background: GP2 (Glycoprotein 2), also known as ZAP75, is a 537 amino acid secreted protein. It is an integral membrane protein that is secreted from intracellular zymogen granules and associates with the plasma membrane via glycosylphosphatidylinositol (GPI) linkage. GP2 is cleaved and then released into the pancreatic duct along with exocrine secretions. GP2 binds pathogens such as enterobacteria, thereby playing an important role in the innate immune response. The C-terminus of this protein is related to the C-terminus of the protein encoded by the neighboring gene, uromodulin (UMOD). GP2 is also expressed on the apical plasma membrane of specialized microfold (M) cells among enterocytes and serves as a transcytotic receptor for mucosal antigens. M cells are considered a promising target for oral vaccination against various infectious diseases.