Angiotensin I Converting Enzyme 1 antibody (AA 1274-1306)

Catalog No. ABIN3029960

The Rabbit Polyclonal anti-Angiotensin I Converting Enzyme 1 antibody has been validated for WB and ELISA. It is suitable to detect Angiotensin I Converting Enzyme 1 in samples from Human and Mouse.

Quick Overview for Angiotensin I Converting Enzyme 1 antibody (AA 1274-1306) (ABIN3029960)

Target: Angiotensin I Converting Enzyme 1 (ACE) (Angiotensin I Converting Enzyme (Peptidyl-Dipeptidase A) 1 (ACE))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Angiotensin I Converting Enzyme 1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-Angiotensin I Converting Enzyme 1 Antibody

Binding Specificity: AA 1274-1306

Purification: Purified

Immunogen: A portion of amino acids 1274-1306 from the human protein was used as the immunogen for this ACE antibody.

Isotype: Ig Fraction

Application Details

Application Notes: Titration of the ACE antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the ACE antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Target Details for Angiotensin I Converting Enzyme 1

Target: Angiotensin I Converting Enzyme 1 (ACE) (Angiotensin I Converting Enzyme (Peptidyl-Dipeptidase A) 1 (ACE))

Alternative Name: ACE

Background: ACE is an enzyme involved in catalyzing the conversion of angiotensin I into a physiologically active peptide angiotensin II. Angiotensin II is a potent vasopressor and aldosterone-stimulating peptide that controls blood pressure and fluid-electrolyte balance. This enzyme plays a key role in the renin-angiotensin system. Many studies have associated the presence or absence of a 287 bp Alu repeat element in this gene with the levels of circulating enzyme or cardiovascular pathophysiologies. Two most abundant alternatively spliced variants of this gene encode two isozymes - the somatic form and the testicular form that are equally active.

UniProt: P12821

Pathways: ACE Inhibitor Pathway, Peptide Hormone Metabolism, Regulation of Systemic Arterial Blood Pressure by Hormones, Feeding Behaviour, Smooth Muscle Cell Migration