AMACR antibody (AA 323-351)

Catalog No. ABIN3029920

This Rabbit Polyclonal antibody specifically detects AMACR in WB, IHC, ELISA, IF and FACS. It exhibits reactivity toward Human.

Quick Overview for AMACR antibody (AA 323-351) (ABIN3029920)

Target: AMACR (alpha-Methylacyl-CoA Racemase (AMACR))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This AMACR antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF), Flow Cytometry (FACS)

Product Details anti-AMACR Antibody

Binding Specificity: AA 323-351

Purification: Antigen affinity purified

Immunogen: A portion of amino acids 323-351 from the human protein was used as the immunogen for this AMACR antibody.

Isotype: Ig Fraction

Application Details

Application Notes: Titration of the AMACR antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000,IHC (Paraffin): 1:50-1:100,Flow Cytometry: 1:10-1:50,Immunofluorescence: 1:10-1:50

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the AMACR antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Target Details for AMACR

Target: AMACR (alpha-Methylacyl-CoA Racemase (AMACR))

Alternative Name: AMACR

Background: This gene encodes a racemase. The encoded enzyme interconverts pristanoyl-CoA and C27-bile acylCoAs between their (R)- and (S)-stereoisomers. The conversion to the (S)-stereoisomers is necessary for degradation of these substrates by peroxisomal beta-oxidation. Encoded proteins from this locus localize to both mitochondria and peroxisomes. Mutations in this gene may be associated with adult-onset sensorimotor neuropathy, pigmentary retinopathy, and adrenomyeloneuropathy due to defects in bile acid synthesis. Alternatively spliced transcript variants have been described.

UniProt: Q9UHK6

Pathways: Monocarboxylic Acid Catabolic Process