AMACR antibody

Catalog No. ABIN7201086

The Mouse Monoclonal anti-AMACR antibody is suitable to detect AMACR in samples from Human, Mouse and Rat. It has been validated for WB, IHC and IF.

Quick Overview for AMACR antibody (ABIN7201086)

Target: AMACR (alpha-Methylacyl-CoA Racemase (AMACR))

Reactivity: Human, Mouse, Rat

Host: Mouse

Clonality: Monoclonal

Conjugate: This AMACR antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details anti-AMACR Antibody

Purpose: Mouse Anti-AMACR Monoclonal Antibody

Specificity: The antibody detects endogenous AMCAR/P504S proteins.

Purification: The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.

Immunogen: Synthetic Peptide

Isotype: IgG1

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:1000,IHC 1:200,IF 1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS, pH 7.4, containing 0.5 % BSA, 0.02 % sodium azide as Preservative and 50 % Glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for AMACR

Target: AMACR (alpha-Methylacyl-CoA Racemase (AMACR))

Alternative Name: AMACR

Background: AMACR, Alpha-methylacyl-CoA racemase, 2-methylacyl-CoA racemaseAMACR encodes a racemase. Alpha-methylacyl-CoA racemase interconverts pristanoyl-CoA and C27-bile acylCoAs between their (R)- and (S)-stereoisomers. The conversion to the (S)-stereoisomers is necessary for degradation of these substrates by peroxisomal beta-oxidation. Alpha-methylacyl-CoA racemase from this locus localize to both mitochondria and peroxisomes. Mutations in AMACR may be associated with adult-onset sensorimotor neuropathy, pigmentary retinopathy, and adrenomyeloneuropathy due to defects in bile acid synthesis. Alternatively spliced transcript variants have been described. Read-through transcription also exists between AMACR and the upstream neighboring C1QTNF3 (C1q and tumor necrosis factor related protein 3) gene.

Molecular Weight: 42kD

Gene ID: 23600

UniProt: Q9UHK6

Pathways: Monocarboxylic Acid Catabolic Process