APP antibody (AA 736-770)

Catalog No. ABIN3029926

This Rabbit Polyclonal antibody specifically detects APP in WB and ELISA. It exhibits reactivity toward Human.

Quick Overview for APP antibody (AA 736-770) (ABIN3029926)

Target: APP (Amyloid beta (A4) Precursor Protein (APP))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This APP antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-APP Antibody

Binding Specificity: AA 736-770

Cross-Reactivity (Details): Expected species reactivity: Mouse, Pig, Primate, Rat

Purification: Purified

Immunogen: A portion of amino acids 736-770 from the human protein was used as the immunogen for this Amyloid beta antibody.

Isotype: Ig Fraction

Application Details

Application Notes: Titration of the Amyloid beta antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the Amyloid beta antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Target Details for APP

Target: APP (Amyloid beta (A4) Precursor Protein (APP))

Alternative Name: Amyloid beta Precusor Protein (APP)

Background: APP is a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Aβ, is the main component of amyloid plaques (extracellular deposits found in the brains of patients with Alzheimer's disease).[19] Similar plaques appear in some variants of Lewy body dementia and in inclusion body myositis (a muscle disease), while Aβ, can also form the aggregates that coat cerebral blood vessels in cerebral amyloid angiopathy. [Wiki]

UniProt: P05067

Pathways: Caspase Cascade in Apoptosis, EGFR Signaling Pathway, Transition Metal Ion Homeostasis, Skeletal Muscle Fiber Development, Toll-Like Receptors Cascades, Feeding Behaviour