Aurora Kinase B antibody (AA 84-111)

Catalog No. ABIN3030074

The Rabbit Polyclonal anti-Aurora Kinase B antibody is suitable to detect Aurora Kinase B in samples from Human and Mouse. It has been validated for WB and ELISA.

Quick Overview for Aurora Kinase B antibody (AA 84-111) (ABIN3030074)

Target: Aurora Kinase B (AURKB)

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Aurora Kinase B antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-Aurora Kinase B Antibody

Binding Specificity: AA 84-111

Purpose: Aurkb Antibody

Cross-Reactivity (Details): Expected species reactivity: Rat

Purification: Antigen affinity

Immunogen: A portion of amino acids 84-111 from the mouse protein was used as the immunogen for this Aurkb antibody.

Isotype: Ig Fraction

Application Details

Application Notes: Titration of the Aurkb antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the Aurkb antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for Aurora Kinase B

Target: Aurora Kinase B (AURKB)

Alternative Name: Aurkb

Background: Aurkb may be directly involved in regulating the cleavage of polar spindle microtubules and is a key regulator for the onset of cytokinesis during mitosis. Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly (By similarity). Phosphorylates 'Ser-10' and 'Ser-28' of histone H3 during mitosis. Required for kinetochore localization of BUB1 and SGOL1 (By similarity).

UniProt: O70126

Pathways: TCR Signaling, Cell Division Cycle, Maintenance of Protein Location, Hepatitis C, Toll-Like Receptors Cascades