Bcl-2 antibody (AA 86-114)

Catalog No. ABIN3030099

This anti-Bcl-2 antibody is a Rabbit Polyclonal antibody detecting Bcl-2 in WB and ELISA. Suitable for Human and Mouse.

Quick Overview for Bcl-2 antibody (AA 86-114) (ABIN3030099)

Target: Bcl-2 (BCL2) (B-Cell CLL/lymphoma 2 (BCL2))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Bcl-2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-Bcl-2 Antibody

Binding Specificity: AA 86-114

Cross-Reactivity (Details): Expected species reactivity: Bovine, Hamster, Rat

Purification: Antigen affinity purified

Immunogen: A portion of amino acids 86-114 from the human protein was used as the immunogen for this BCL2 antibody.

Isotype: Ig Fraction

Application Details

Application Notes: Titration of the BCL2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In 1X PBS pH 7.4 with 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the BCL2 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Target Details for Bcl-2

Target: Bcl-2 (BCL2) (B-Cell CLL/lymphoma 2 (BCL2))

Alternative Name: BCL2

Background: This gene encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. Two transcript variants, produced by alternate splicing, differ in their C-terminal ends. [provided by RefSeq].

UniProt: P10415

Pathways: MAPK Signaling, PI3K-Akt Signaling, Apoptosis, Caspase Cascade in Apoptosis, Regulation of Muscle Cell Differentiation, Cell-Cell Junction Organization, Skeletal Muscle Fiber Development, Autophagy, Smooth Muscle Cell Migration, Negative Regulation of intrinsic apoptotic Signaling