DCLK1 antibody (AA 153-181)

Catalog No. ABIN3030771

This anti-DCLK1 antibody is a Rabbit Polyclonal antibody detecting DCLK1 in WB and ELISA. Suitable for Mouse.

Quick Overview for DCLK1 antibody (AA 153-181) (ABIN3030771)

Target: DCLK1 (Doublecortin-Like Kinase 1 (DCLK1))

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DCLK1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-DCLK1 Antibody

Binding Specificity: AA 153-181

Purification: Antigen affinity purified

Immunogen: A portion of amino acids 153-181 from the mouse protein was used as the immunogen for this Dclk1 antibody.

Isotype: Ig Fraction

Application Details

Application Notes: Titration of the Dclk1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the Dclk1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Target Details for DCLK1

Target: DCLK1 (Doublecortin-Like Kinase 1 (DCLK1))

Alternative Name: Dclk1

Background: This gene encodes a member of the protein kinase superfamily and the doublecortin family. The protein encoded by this gene contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmodulin-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. The microtubule-polymerizing activity of the encoded protein is independent of its protein kinase activity. The encoded protein is involved in several different cellular processes, including neuronal migration, retrograde transport, neuronal apoptosis and neurogenesis. This gene is up-regulated by brain-derived neurotrophic factor and associated with memory and general cognitive abilities. Multiple transcript variants generated by two alternative promoter usage and alternative splicing have been found, but the biological validity of some variants has not been determined. These variants encode different isoforms, which are differentially expressed and have different kinase activities.

UniProt: Q9JLM8