Dynamin 1-Like antibody (C-Term)

Catalog No. ABIN3030780

This anti-Dynamin 1-Like antibody is a Rabbit Polyclonal antibody detecting Dynamin 1-Like in WB and ELISA. Suitable for Human, Mouse and Rat.

Quick Overview for Dynamin 1-Like antibody (C-Term) (ABIN3030780)

Target: Dynamin 1-Like (DNM1L)

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Dynamin 1-Like antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-Dynamin 1-Like Antibody

Binding Specificity: C-Term

Purification: Antigen affinity purified

Immunogen: This DNM1L antibody was produced from a rabbit immunized with a KLH conjugated synthetic peptide between 513-547 amino acids from the C-terminal region of human DRP1/DNM1L.

Isotype: Ig Fraction

Application Details

Application Notes: Titration of the DNM1L antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:8000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the DNM1L antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Target Details for Dynamin 1-Like

Target: Dynamin 1-Like (DNM1L)

Alternative Name: DNM1L

Background: Functions in mitochondrial and peroxisomal division. Mediates membrane fission through oligomerization into membrane- associated tubular structures that wrap around the scission site to constrict and sever the mitochondrial membrane through a GTP hydrolysis-dependent mechanism. Through its function in mitochondrial division, ensures the survival of at least some types of postmitotic neurons, including Purkinje cells, by suppressing oxidative damage. Required for normal brain development, including that of cerebellum. Facilitates developmentally regulated apoptosis during neural tube formation. Required for a normal rate of cytochrome c release and caspase activation during apoptosis, this requirement may depend upon the cell type and the physiological apoptotic cues. Also required for mitochondrial fission during mitosis. Required for formation of endocytic vesicles. Proposed to regulate synaptic vesicle membrane dynamics through association with BCL2L1 isoform Bcl-X(L) which stimulates its GTPase activity in synaptic vesicles, the function may require its recruitment by MFF to clathrin-containing vesicles. Required for programmed necrosis execution. [UniProt]

UniProt: O00429