EPH Receptor A2 antibody (AA 296-323)

Catalog No. ABIN3030814

This Rabbit Polyclonal antibody specifically detects EPH Receptor A2 in WB and ELISA. It exhibits reactivity toward Mouse.

Quick Overview for EPH Receptor A2 antibody (AA 296-323) (ABIN3030814)

Target: EPH Receptor A2 (EPHA2)

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This EPH Receptor A2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-EPH Receptor A2 Antibody

Binding Specificity: AA 296-323

Purification: Antigen affinity purified

Immunogen: A portion of amino acids 296-323 from the mouse protein was used as the immunogen for this Epha2 antibody.

Isotype: Ig Fraction

Application Details

Application Notes: Titration of the Epha2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the Epha2 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Target Details for EPH Receptor A2

Target: EPH Receptor A2 (EPHA2)

Alternative Name: Epha2

Background: Receptor for members of the ephrin-A family. Binds to ephrin-A1, -A3, -A4 and -A5. Induces apoptosis in a TP53/p53-independent, caspase-8-dependent manner (By similarity). Plays an important role in angiogenesis and tumor neovascularization. The recruitement of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly. May function in distinctive aspects of pattern formation and subsequently in development of several fetal tissues. May be involved in cell-cell interactions guiding early hindbrain development.

UniProt: Q03145

Pathways: RTK Signaling