EPH Receptor B1 antibody (AA 374-409)

Catalog No. ABIN3030823

This Rabbit Polyclonal antibody specifically detects EPH Receptor B1 in WB and ELISA. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for EPH Receptor B1 antibody (AA 374-409) (ABIN3030823)

Target: EPH Receptor B1 (EPHB1)

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This EPH Receptor B1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-EPH Receptor B1 Antibody

Binding Specificity: AA 374-409

Cross-Reactivity (Details): Expected species reactivity: Chicken

Purification: Antigen affinity purified

Immunogen: A portion of amino acids 374-409 from the mouse protein were used as the immunogen for the Ephb1 antibody.

Isotype: Ig Fraction

Application Details

Application Notes: Titration of the Ephb1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the Ephb1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Target Details for EPH Receptor B1

Target: EPH Receptor B1 (EPHB1)

Alternative Name: Ephb1

Background: Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Cognate/functional ephrin ligands for this receptor include EFNB1, EFNB2 and EFNB3. During nervous system development, regulates retinal axon guidance redirecting ipsilaterally ventrotemporal retinal ganglion cells axons at the optic chiasm midline. This probably requires repulsive interaction with EFNB2. In the adult nervous system together with EFNB3, regulates chemotaxis, proliferation and polarity of the hippocampus neural progenitors. Beside its role in axon guidance plays also an important redundant role with other ephrin-B receptors in development and maturation of dendritic spines and synapse formation. May also regulate angiogenesis. More generally, may play a role in targeted cell migration and adhesion. Upon activation by EFNB1 and probably other ephrin-B ligands activates the MAPK/ERK and the JNK signaling cascades to regulate cell migration and adhesion respectively.

UniProt: Q8CBF3

Pathways: RTK Signaling