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FGFR3 antibody (AA 449-482)

FGFR3 Reactivity: Human WB, ELISA Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN3030955
  • Target See all FGFR3 Antibodies
    FGFR3 (Fibroblast Growth Factor Receptor 3 (FGFR3))
    Binding Specificity
    • 17
    • 15
    • 8
    • 8
    • 8
    • 8
    • 7
    • 7
    • 7
    • 6
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 449-482
    Reactivity
    • 110
    • 50
    • 42
    • 4
    • 1
    • 1
    • 1
    Human
    Host
    • 103
    • 7
    • 1
    Rabbit
    Clonality
    • 92
    • 19
    Polyclonal
    Conjugate
    • 39
    • 12
    • 8
    • 6
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    This FGFR3 antibody is un-conjugated
    Application
    • 81
    • 42
    • 40
    • 13
    • 13
    • 10
    • 10
    • 7
    • 5
    • 3
    • 3
    • 2
    • 2
    • 1
    Western Blotting (WB), ELISA
    Purification
    Antigen affinity purified
    Immunogen
    This FGFR3 antibody was produced from a rabbit immunized with a KLH conjugated synthetic peptide between 449-482 amino acids from the central region of mouse Fgfr3.
    Isotype
    Ig Fraction
    Top Product
    Discover our top product FGFR3 Primary Antibody
  • Application Notes
    Titration of the FGFR3 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    In 1X PBS, pH 7.4, with 0.09 % sodium azide
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Aliquot the FGFR3 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
  • Target
    FGFR3 (Fibroblast Growth Factor Receptor 3 (FGFR3))
    Alternative Name
    FGFR3 (FGFR3 Products)
    Synonyms
    FGFR3 antibody, LOC100034114 antibody, ACH antibody, CD333 antibody, CEK2 antibody, HSFGFR3EX antibody, JTK4 antibody, FR3 antibody, Fgfr-3 antibody, Flg-2 antibody, HBGFR antibody, Mfr3 antibody, sam3 antibody, fc27h01 antibody, wu:fc27h01 antibody, fibroblast growth factor receptor 3 antibody, fibroblast growth factor receptor 3 (achondroplasia, thanatophoric dwarfism) S homeolog antibody, FGFR3 antibody, fgfr3.S antibody, Fgfr3 antibody, fgfr3 antibody
    Background
    Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation and apoptosis. Plays an essential role in the regulation of chondrocyte differentiation, proliferation and apoptosis, and is required for normal skeleton development. Regulates both osteogenesis and postnatal bone mineralization by osteoblasts. Promotes apoptosis in chondrocytes, but can also promote cancer cell proliferation. Required for normal development of the inner ear. Phosphorylates PLCG1, CBL and FRS2. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Plays a role in the regulation of vitamin D metabolism. Mutations that lead to constitutive kinase activation or impair normal FGFR3 maturation, internalization and degradation lead to aberrant signaling. Over-expressed or constitutively activated FGFR3 promotes activation of STAT1, STAT5A and STAT5B. Plays a role in postnatal lung development.
    UniProt
    Q61851
    Pathways
    RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Stem Cell Maintenance, Growth Factor Binding
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