Glypican 3 antibody (AA 465-494)

Catalog No. ABIN3031097

The Rabbit Polyclonal anti-Glypican 3 antibody has been validated for WB and ELISA. It is suitable to detect Glypican 3 in samples from Human.

Quick Overview for Glypican 3 antibody (AA 465-494) (ABIN3031097)

Target: Glypican 3 (GPC3)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Glypican 3 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-Glypican 3 Antibody

Binding Specificity: AA 465-494

Purification: Antigen affinity purified

Immunogen: A portion of amino acids 465-494 from the human protein was used as the immunogen for this GPC3 antibody.

Isotype: Ig Fraction

Application Details

Application Notes: Titration of the GPC3 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the GPC3 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Target Details for Glypican 3

Target: Glypican 3 (GPC3)

Alternative Name: GPC3

Background: Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation. The protein encoded by this gene can bind to and inhibit the dipeptidyl peptidase activity of CD26, and it can induce apoptosis in certain cell types. Deletion mutations in this gene are associated with Simpson-Golabi-Behmel syndrome, also known as Simpson dysmorphia syndrome. Alternative splicing results in multiple transcript variants.

UniProt: P51654

Pathways: Glycosaminoglycan Metabolic Process