GSK3 beta antibody (AA 4-34)

Catalog No. ABIN3031095

Product Details anti-GSK3 beta Antibody

Target: GSK3 beta (GSK3b) (Glycogen Synthase Kinase 3 beta (GSK3b))

Binding Specificity: AA 4-34

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GSK3 beta antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Cross-Reactivity (Details): Expected species reactivity: Mouse, Rat

Purification: Antigen affinity purified

Immunogen: A portion of amino acids 4-34 from the human protein was used as the immunogen for this GSK3B antibody.

Isotype: Ig Fraction

Application Details

Application Notes: Titration of the GSK3B antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000,IHC (Paraffin): 1:50-1:100

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the GSK3B antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Target Details for GSK3 beta

Target: GSK3 beta (GSK3b) (Glycogen Synthase Kinase 3 beta (GSK3b))

Alternative Name: GSK3B (GSK3b Products)

Background: GSK3B is a constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), EIF2B, CTNNB1/beta-catenin, APC, AXIN1, DPYSL2/CRMP2, JUN, NFATC1/NFATC, MAPT/TAU and MACF1. May also mediate the development of insulin resistance by regulating activation of transcription factors. [UniProt]

UniProt: P49841

Pathways: WNT Signaling, Hedgehog Signaling, Fc-epsilon Receptor Signaling Pathway, Cellular Glucan Metabolic Process, ER-Nucleus Signaling, Regulation of Carbohydrate Metabolic Process, Hepatitis C, Autophagy, BCR Signaling, Warburg Effect