JMJD2D antibody (AA 484-516)

Catalog No. ABIN3031654

This Rabbit Polyclonal antibody specifically detects JMJD2D in ELISA and WB. It exhibits reactivity toward Human.

Quick Overview for JMJD2D antibody (AA 484-516) (ABIN3031654)

Target: JMJD2D (KDM4D) (Lysine (K)-Specific Demethylase 4D (KDM4D))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This JMJD2D antibody is un-conjugated

Application: ELISA, Western Blotting (WB)

Product Details anti-JMJD2D Antibody

Binding Specificity: AA 484-516

Purification: Purified

Immunogen: A portion of amino acids 484-516 from the human protein was used as the immunogen for this JMJD2D antibody.

Isotype: Ig Fraction

Application Details

Application Notes: Titration of the JMJD2D antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In 1X PBS pH 7.4 with 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the JMJD2D antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Target Details for JMJD2D

Target: JMJD2D (KDM4D) (Lysine (K)-Specific Demethylase 4D (KDM4D))

Alternative Name: JMJD2D (KDM4D)

Background: Covalent modification of histones plays critical role in regulating chromatin structure and transcription. While most covalent histone modifications are reversible, only recently has it been established that methyl groups are subject to enzymatic removal from histones. A family of novel JmjC domain-containing histone demethylation (JHDM) enzymes have been identified that perform this specific function. Histone demethylation by JHDM proteins requires cofactors Fe(II) and alpha-ketoglutarate. Family members include JHDM1 (demethylating histone 3 at lysine 36), and JHDM2A as well as JMJD2CH3K9 (both of which demethylate histone 3 at lysine 9). Contributions of histone demethylase activity to tumor development, decreases in cell proliferation, and hormone-dependent transcriptional activation have been observed.

UniProt: Q6B0I6

Pathways: Warburg Effect