Lamin A/C antibody (AA 465-498)

Catalog No. ABIN3031584

This anti-Lamin A/C antibody is a Rabbit Polyclonal antibody detecting Lamin A/C in WB and ELISA. Suitable for Human.

Quick Overview for Lamin A/C antibody (AA 465-498) (ABIN3031584)

Target: Lamin A/C (LMNA)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Lamin A/C antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-Lamin A/C Antibody

Binding Specificity: AA 465-498

Purification: Antigen affinity purified

Immunogen: This Lamin A/C antibody was produced from a rabbit immunized with a KLH conjugated synthetic peptide between 465-498 amino acids from the Central region of the human protein.

Isotype: Ig Fraction

Application Details

Application Notes: Titration of the Lamin A/C antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:500-1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the Lamin A/C antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Target Details for Lamin A/C

Target: Lamin A/C (LMNA)

Alternative Name: Lamin A/C

Background: Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin. Lamin A and C are present in equal amounts in the lamina of mammals. Plays an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics. Required for normal development of peripheral nervous system and skeletal muscle and for muscle satellite cell proliferation. Required for osteoblastogenesis and bone formation. Also prevents fat infiltration of muscle and bone marrow, helping to maintain the volume and strength of skeletal muscle and bone.

UniProt: P02545

Pathways: Apoptosis, Caspase Cascade in Apoptosis, ER-Nucleus Signaling, Protein targeting to Nucleus