Leptin Receptor antibody (AA 23-52)

Catalog No. ABIN3031603

This Rabbit Polyclonal antibody specifically detects Leptin Receptor in WB, ELISA, IHC and FACS. It exhibits reactivity toward Human.

Quick Overview for Leptin Receptor antibody (AA 23-52) (ABIN3031603)

Target: Leptin Receptor (LEPR)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Leptin Receptor antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Flow Cytometry (FACS)

Product Details anti-Leptin Receptor Antibody

Binding Specificity: AA 23-52

Purification: Purified

Immunogen: A portion of amino acids 23-52 from the human protein was used as the immunogen for this Leptin Receptor antibody.

Isotype: Ig Fraction

Application Details

Application Notes: Titration of the Leptin Receptor antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000,Flow Cytometry: 1:10-1:50,IHC (Paraffin): 1:50-1:100

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the Leptin Receptor antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Target Details for Leptin Receptor

Target: Leptin Receptor (LEPR)

Alternative Name: Leptin Receptor

Background: Leptin, an adipocyte-specific hormone, regulates adipose-tissue mass through hypothalamic effects on satiety and energy expenditure by acting through the leptin receptor (LEPR). LEPR is a single-transmembrane-domain receptor of the cytokine receptor family that is identical to the mouse diabetes (db) gene product. During weight loss, leptin levels decrease, whereas soluble LEPR levels and the receptor bound fraction of leptin increases. The presence of LEPR in the absorptive cells of the small intestine suggests that leptin may have a physiological role in the regulation of nutrient absorption.

UniProt: P48357

Pathways: JAK-STAT Signaling, AMPK Signaling, Feeding Behaviour