MECP2 antibody (AA 58-87)
Quick Overview for MECP2 antibody (AA 58-87) (ABIN3031763)
Target
See all MECP2 AntibodiesReactivity
Host
Clonality
Conjugate
Application
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Binding Specificity
- AA 58-87
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Purpose
- MeCP2 Antibody
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Cross-Reactivity (Details)
- Expected species reactivity: Mouse, Rat, Primate
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Purification
- Antigen affinity
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Immunogen
- A portion of amino acids 58-87 from the human protein was used as the immunogen for this MeCP2 antibody.
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Isotype
- Ig Fraction
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Application Notes
- Titration of the MeCP2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
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Restrictions
- For Research Use only
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Format
- Liquid
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Buffer
- In 1X PBS, pH 7.4, with 0.09 % sodium azide
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Preservative
- Sodium azide
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Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Storage
- -20 °C
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Storage Comment
- Aliquot the MeCP2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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- MECP2 (Methyl CpG Binding Protein 2 (MECP2))
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Alternative Name
- MeCP2
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Background
- MeCP2 is a chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Mediates transcriptional repression through interaction with histone deacetylase and the corepressor SIN3A. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). [UniProt]
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UniProt
- P51608
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Pathways
- Inositol Metabolic Process, Chromatin Binding, Synaptic Membrane
Target
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