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NEK2 antibody (AA 350-382)

NEK2 Reactivity: Human WB, ELISA Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN3031999
  • Target See all NEK2 Antibodies
    NEK2 (NIMA (Never in Mitosis Gene A)-Related Kinase 2 (NEK2))
    Binding Specificity
    • 15
    • 8
    • 7
    • 6
    • 6
    • 6
    • 5
    • 4
    • 4
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 350-382
    Reactivity
    • 91
    • 18
    • 14
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    Human
    Host
    • 84
    • 7
    • 2
    Rabbit
    Clonality
    • 86
    • 7
    Polyclonal
    Conjugate
    • 39
    • 8
    • 6
    • 6
    • 5
    • 5
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This NEK2 antibody is un-conjugated
    Application
    • 78
    • 42
    • 15
    • 14
    • 13
    • 12
    • 10
    • 4
    • 4
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB), ELISA
    Purification
    Purified
    Immunogen
    A portion of amino acids 350-382 from the human protein was used as the immunogen for this NEK2 antibody.
    Isotype
    Ig Fraction
    Top Product
    Discover our top product NEK2 Primary Antibody
  • Application Notes
    Titration of the NEK2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    In 1X PBS pH 7.4 with 0.09 % sodium azide
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Aliquot the NEK2 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
  • Target
    NEK2 (NIMA (Never in Mitosis Gene A)-Related Kinase 2 (NEK2))
    Alternative Name
    NEK2 (NEK2 Products)
    Synonyms
    AA617254 antibody, C77054 antibody, HsPK21 antibody, NEK2A antibody, NLK1 antibody, ATNEK2 antibody, NIMA-RELATED KINASE2 antibody, NIMA-related kinase 2 antibody, T9J14.24 antibody, T9J14_24 antibody, NIMA related kinase 2 antibody, NIMA (never in mitosis gene a)-related expressed kinase 2 antibody, NIMA-related kinase 2 antibody, NEK2 antibody, Nek2 antibody
    Background
    NEK2 is closely related in its catalytic domain to the serine/threonine protein kinase NIMA of Aspergillus nidulans which is required for entry into mitosis and may function in parallel to the universal mitotic inducer p34cdc2. Like NIMA, the Nek2 protein is almost undetectable during G1 but accumulates progressively throughout S, reaching maximal levels in late G2. These observations demonstrate that NEK2 resembles Aspergillus NIMA, both in its catalytic domain, and cell cycle-dependent expression. Recombinant NEK2 is active as a serine/threonine-specific protein kinase and may undergo autophosphorylation. Both human NEK2 and fungal NIMA phosphorylate a similar, but not identical, set of proteins and synthetic peptides. NEK2 is shown to be expressed most abundantly in adult testis and there is increasing evidence that NEK2 is abnormally expressed in a wide variety of human cancers. This antibody is specific to isoform 2 of NEK2.
    UniProt
    P51955
    Pathways
    M Phase
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