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MME antibody (AA 506-534)

MME Reactivity: Human FACS, WB, IHC, ELISA Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN3031746
  • Target See all MME Antibodies
    MME (Membrane Metallo-Endopeptidase (MME))
    Binding Specificity
    • 14
    • 9
    • 8
    • 7
    • 7
    • 7
    • 7
    • 6
    • 6
    • 5
    • 4
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 506-534
    Reactivity
    • 183
    • 38
    • 31
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Human
    Host
    • 99
    • 89
    • 2
    Rabbit
    Clonality
    • 104
    • 85
    • 2
    Polyclonal
    Conjugate
    • 105
    • 18
    • 16
    • 12
    • 9
    • 5
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This MME antibody is un-conjugated
    Application
    • 111
    • 78
    • 75
    • 64
    • 35
    • 27
    • 20
    • 19
    • 10
    • 8
    • 5
    • 5
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Flow Cytometry (FACS), Western Blotting (WB), Immunohistochemistry (IHC), ELISA
    Cross-Reactivity (Details)
    Expected species reactivity: Mouse, Rat, Rabbit
    Purification
    Antigen affinity purified
    Immunogen
    A portion of amino acids 506-534 from the human protein was used as the immunogen for this Neprilysin antibody.
    Isotype
    Ig Fraction
    Top Product
    Discover our top product MME Primary Antibody
  • Application Notes
    Titration of the Neprilysin antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000,IHC (Paraffin): 1:50-1:100,Flow Cytometry: 1:10-1:50
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    In 1X PBS, pH 7.4, with 0.09 % sodium azide
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Aliquot the Neprilysin antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
  • Target
    MME (Membrane Metallo-Endopeptidase (MME))
    Alternative Name
    Neprilysin (MME Products)
    Synonyms
    CALLA antibody, CD10 antibody, NEP antibody, SFE antibody, 6030454K05Rik antibody, C85356 antibody, Nep antibody, neprilysin antibody, membrane metalloendopeptidase antibody, membrane metallo endopeptidase antibody, membrane metallo-endopeptidase antibody, MME antibody, Mme antibody
    Target Type
    Chemical
    Background
    MME is a common acute lymphocytic leukemia antigen that is an important cell surface marker in the diagnosis of human acute lymphocytic leukemia (ALL). This protein is present on leukemic cells of pre-B phenotype, which represent 85 % of cases of ALL. This protein is not restricted to leukemic cells, however, and is found on a variety of normal tissues. It is a oprotein that is particularly abundant in kidney, where it is present on the brush border of proximal tubules and on glomerular epithelium. The protein is a neutral endopeptidase that cleaves peptides at the amino side of hydrophobic residues and inactivates several peptide hormones including glucagon, enkephalins, substance P, neurotensin, oxytocin, and bradykinin.
    UniProt
    P08473
    Pathways
    RTK Signaling, Peptide Hormone Metabolism, Regulation of Systemic Arterial Blood Pressure by Hormones, Smooth Muscle Cell Migration
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