MME antibody (AA 506-534)

Catalog No. ABIN3031746

The Rabbit Polyclonal anti-MME antibody (ABIN3031746) specifically detects MME in WB, IHC, FACS and ELISA. The antibody is reactive with Human samples.

Quick Overview for MME antibody (AA 506-534) (ABIN3031746)

Target: MME (Membrane Metallo-Endopeptidase (MME))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MME antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS), ELISA

Product Details anti-MME Antibody

Binding Specificity: AA 506-534

Purpose: Neprilysin Antibody

Cross-Reactivity (Details): Expected species reactivity: Mouse, Rat, Rabbit

Purification: Antigen affinity

Immunogen: A portion of amino acids 506-534 from the human protein was used as the immunogen for this Neprilysin antibody.

Isotype: Ig Fraction

Application Details

Application Notes: Titration of the Neprilysin antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the Neprilysin antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for MME

Target: MME (Membrane Metallo-Endopeptidase (MME))

Alternative Name: Neprilysin

Target Type: Chemical

Background: MME is a common acute lymphocytic leukemia antigen that is an important cell surface marker in the diagnosis of human acute lymphocytic leukemia (ALL). This protein is present on leukemic cells of pre-B phenotype, which represent 85 % of cases of ALL. This protein is not restricted to leukemic cells, however, and is found on a variety of normal tissues. It is a oprotein that is particularly abundant in kidney, where it is present on the brush border of proximal tubules and on glomerular epithelium. The protein is a neutral endopeptidase that cleaves peptides at the amino side of hydrophobic residues and inactivates several peptide hormones including glucagon, enkephalins, substance P, neurotensin, oxytocin, and bradykinin.

UniProt: P08473

Pathways: RTK Signaling, Peptide Hormone Metabolism, Regulation of Systemic Arterial Blood Pressure by Hormones, Smooth Muscle Cell Migration