NOTCH3 antibody (AA 2291-2321)

Catalog No. ABIN3032031

The Mouse Monoclonal anti-NOTCH3 antibody (Clone 487CT6-9-2) (ABIN3032031) specifically detects NOTCH3 in WB and ELISA. The antibody is reactive with Human samples.

Quick Overview for NOTCH3 antibody (AA 2291-2321) (ABIN3032031)

Target: NOTCH3 (Notch 3 (NOTCH3))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This NOTCH3 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Clone: 487CT6-9-2

Product Details anti-NOTCH3 Antibody

Binding Specificity: AA 2291-2321

Purpose: NOTCH3 Antibody

Purification: Purified

Immunogen: A portion of amino acids 2291-2321 from the human protein was used as the immunogen for this NOTCH3 antibody.

Isotype: IgG1

Application Details

Application Notes: Titration of the NOTCH3 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the NOTCH3 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for NOTCH3

Target: NOTCH3 (Notch 3 (NOTCH3))

Alternative Name: NOTCH3

Background: This gene encodes the third discovered human homologue of the Drosophilia melanogaster type I membrane protein notch. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signalling pathway that plays a key role in neural development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remains to be determined. Mutations in NOTCH3 have been identified as the underlying cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). [provided by RefSeq].

UniProt: Q9UM47

Pathways: Notch Signaling