PARP1 antibody (pSer41)

Catalog No. ABIN3032270

The Rabbit Polyclonal anti-PARP1 antibody is suitable to detect PARP1 in samples from Human. It has been validated for ELISA and DB.

Quick Overview for PARP1 antibody (pSer41) (ABIN3032270)

Target: PARP1 (Poly (ADP-Ribose) Polymerase 1 (PARP1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PARP1 antibody is un-conjugated

Application: ELISA, Dot Blot (DB)

Product Details anti-PARP1 Antibody

Binding Specificity: pSer41

Purpose: Phospho-PARP1 Antibody (pS41)

Predicted Reactivity: Mouse,Rat,Hamster

Purification: Antigen affinity purified

Immunogen: This Phospho-PARP1 (S41) Antibody was produced from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding pS41 of human PARP1.

Isotype: Ig Fraction

Application Details

Application Notes: Titration of the Phospho-PARP1 (S41) Antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles

Storage: -20 °C

Storage Comment: Aliquot the Phospho-PARP1 (S41) Antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for PARP1

Target: PARP1 (Poly (ADP-Ribose) Polymerase 1 (PARP1))

Alternative Name: PARP

Background: Phospho-PARP1 (S41) Antibody specifically detects PARP1 protein phosphorylated at the serine 41 site. This gene encodes a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes.

Phosphorylation-dependent PARP1 signaling studies may also benefit from our < a href=../tds/phospho-parp-antibody-ps177-f48726>phospho-PARP1 (Ser177) antibody page focused on DNA damage response and chromatin stress pathway regulation.

UniProt: P09874

Pathways: Apoptosis, Caspase Cascade in Apoptosis, DNA Damage Repair, Production of Molecular Mediator of Immune Response, Maintenance of Protein Location