PDGFRA antibody (AA 740-769)

Catalog No. ABIN3032251

This Rabbit Polyclonal antibody specifically detects PDGFRA in WB, ELISA and IHC. It exhibits reactivity toward Human.

Quick Overview for PDGFRA antibody (AA 740-769) (ABIN3032251)

Target: PDGFRA (Platelet Derived Growth Factor Receptor alpha (PDGFRA))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PDGFRA antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Product Details anti-PDGFRA Antibody

Binding Specificity: AA 740-769

Cross-Reactivity (Details): Expected species reactivity: Mouse, Rat, Xenopus

Purification: Antigen affinity purified

Immunogen: A portion of amino acids 740-769 from the human protein was used as the immunogen for this PDGFR alpha antibody.

Isotype: Ig Fraction

Application Details

Application Notes: Titration of the PDGFR alpha antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000,IHC (Paraffin): 1:10-1:50

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the PDGFR alpha antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Target Details for PDGFRA

Target: PDGFRA (Platelet Derived Growth Factor Receptor alpha (PDGFRA))

Alternative Name: PDGFR alpha

Background: PDGFRA is a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. Studies in knockout mice, where homozygosity is lethal, indicate that the alpha form of the platelet-derived growth factor receptor is particularly important for kidney development since mice heterozygous for the receptor exhibit defective kidney phenotypes.

UniProt: P16234

Pathways: RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Platelet-derived growth Factor Receptor Signaling