MUC1 antibody (pThr1224)

Catalog No. ABIN3031864

This Rabbit Polyclonal antibody specifically detects MUC1 in ELISA, IF and DB. It exhibits reactivity toward Human.

Quick Overview for MUC1 antibody (pThr1224) (ABIN3031864)

Target: MUC1 (Mucin 1 (MUC1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MUC1 antibody is un-conjugated

Application: ELISA, Immunofluorescence (IF), Dot Blot (DB)

Product Details anti-MUC1 Antibody

Binding Specificity: pThr1224

Purification: Antigen affinity purified

Immunogen: This phospho-MUC1 antibody was produced from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding pT1224 of human MUC1.

Isotype: Ig Fraction

Application Details

Application Notes: Titration of the phospho-MUC1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Dot blot: 1:500,Immunofluorescence: 1:10-1:50

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the phospho-MUC1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Target Details for MUC1

Target: MUC1 (Mucin 1 (MUC1))

Alternative Name: MUC1

Background: MUC1 is a member of the mucin family and encodes a membrane bound, glycosylated phosphoprotein. The protein is anchored to the apical surface of many epithelia by a transmembrane domain, with the degree of glycosylation varying with cell type. It also includes a 20 aa variable number tandem repeat (VNTR) domain, with the number of repeats varying from 20 to 120 in different individuals. The protein serves a protective function by binding to pathogens and also functions in a cell signaling capacity. Overexpression, aberrant intracellular localization, and changes in glycosylation of this protein have been associated with carcinomas.

UniProt: P15941

Pathways: Negative Regulation of intrinsic apoptotic Signaling