TSC1 antibody (pSer505)

Catalog No. ABIN3029289

The Rabbit Polyclonal anti-TSC1 antibody (ABIN3029289) specifically detects TSC1 in DB and ELISA. The antibody is reactive with Human samples.

Quick Overview for TSC1 antibody (pSer505) (ABIN3029289)

Target: TSC1 (Tuberous Sclerosis 1 (TSC1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TSC1 antibody is un-conjugated

Application: Dot Blot (DB), ELISA

Product Details anti-TSC1 Antibody

Binding Specificity: pSer505

Purpose: Phospho-TSC1 Antibody (pS505)

Cross-Reactivity (Details): Expected species reactivity: Mouse

Purification: Antigen affinity

Immunogen: This phospho-TSC1 antibody was produced from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding pS505 of human TSC1.

Isotype: Ig Fraction

Application Details

Application Notes: Titration of the phospho-TSC1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the phospho-TSC1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for TSC1

Target: TSC1 (Tuberous Sclerosis 1 (TSC1))

Alternative Name: TSC1

Background: TSC1 is implicated as a tumor suppressor, and may have a function in vesicular transport. Interaction between TSC1 and TSC2 may facilitate vesicular docking. Defects in TSC1 are the cause of tuberous sclerosis complex (TSC). The molecular basis of TSC is a functional impairement of the hamartin-tuberin complex. TSC is an autosomal dominant multi-system disorder that affects especially the brain, kidneys, heart, and skin. Defects in TSC1 may be a cause of focal cortical dysplasia of Taylor balloon cell type (FCDBC). FCDBC is a subtype of cortical displasias linked to chronic intractable epilepsy. Cortical dysplasias display a broad spectrum of structural changes, which appear to result from changes in proliferation, migration, differentiation, and apoptosis of neuronal precursors and neurons during cortical development.

UniProt: Q92574

Pathways: RTK Signaling, AMPK Signaling, Regulation of Cell Size, Tube Formation