Tuberin antibody (pSer1096)
Quick Overview for Tuberin antibody (pSer1096) (ABIN3029316)
Target
See all Tuberin (TSC2) AntibodiesReactivity
Host
Clonality
Conjugate
Application
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Binding Specificity
- pSer1096
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Purification
- Antigen affinity purified
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Immunogen
- This phospho-TSC2 antibody was produced from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding pS1096 of mouse TSC2.
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Isotype
- Ig Fraction
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anti-Tuberous Sclerosis 2 (TSC2) (AA 1776-1805) antibody
TSC2 Reactivity: Human WB, IF, IHC (p) Host: Rabbit Polyclonal RB13393 unconjugated
anti-Tuberous Sclerosis 2 (TSC2) (AA 1611-1807) antibodyTSC2 Reactivity: Human, Mouse, Rat WB, IHC Host: Rabbit Polyclonal unconjugated
anti-Tuberous Sclerosis 2 (TSC2) (AA 1601-1750) antibodyTSC2 Reactivity: Human, Mouse, Rat ELISA, IF (cc), IF (p), IHC (p), IHC (fro) Host: Rabbit Polyclonal unconjugated
anti-Tuberous Sclerosis 2 (TSC2) (AA 1776-1805) antibodyTSC2 Reactivity: Human ELISA, WB, IHC, IF Host: Rabbit Polyclonal unconjugated
anti-Tuberous Sclerosis 2 (TSC2) (AA 900-1150) antibodyTSC2 Reactivity: Human WB, IHC, IF Host: Rabbit Polyclonal unconjugated
anti-Tuberous Sclerosis 2 (TSC2) (pThr1462) antibodyTSC2 Reactivity: Human, Mouse, Rat ELISA, WB, IHC, IF, ICC Host: Rabbit Polyclonal unconjugated
anti-Tuberous Sclerosis 2 (TSC2) (pSer1387) antibodyTSC2 Reactivity: Human DB, IF Host: Rabbit Polyclonal RB11388 unconjugated
anti-Tuberous Sclerosis 2 (TSC2) (AA 1397-1426) antibodyTSC2 Reactivity: Human WB, IHC (p) Host: Rabbit Polyclonal RB42388 unconjugated
anti-Tuberous Sclerosis 2 (TSC2) antibodyKD Validated TSC2 Reactivity: Human WB, FACS Host: Rabbit Monoclonal 23GB1120 unconjugated Recombinant Antibody
anti-Tuberous Sclerosis 2 (TSC2) (AA 1396-1496) antibodyTSC2 Reactivity: Human ELISA, WB, IF Host: Rabbit Polyclonal unconjugated
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Application Notes
- Titration of the phospho-TSC2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Dot blot: 1:500
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Restrictions
- For Research Use only
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Format
- Liquid
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Buffer
- In 1X PBS, pH 7.4, with 0.09 % sodium azide
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Preservative
- Sodium azide
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Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Storage
- -20 °C
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Storage Comment
- Aliquot the phospho-TSC2 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
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- Tuberin (TSC2) (Tuberous Sclerosis 2 (TSC2))
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Alternative Name
- TSC2
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Background
- In complex with TSC1, inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling. Acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1. Implicated as a tumor suppressor. Involved in microtubule-mediated protein transport, but this seems to be due to unregulated mTOR signaling (By similarity). Specifically stimulates the intrinsic GTPase activity of the Ras-related protein RAP1A and RAB5. Suggesting a possible mechanism for its role in regulating cellular growth (By similarity).
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UniProt
- Q61037
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Pathways
- RTK Signaling, AMPK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Regulation of Cell Size, Tube Formation, Protein targeting to Nucleus
Target
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