Tuberin antibody (AA 900-1150)

Catalog No. ABIN6149611

The Rabbit Polyclonal anti-Tuberin antibody is suitable to detect Tuberin in samples from Human. It has been validated for WB, IHC and IF.

Quick Overview for Tuberin antibody (AA 900-1150) (ABIN6149611)

Target: Tuberin (TSC2) (Tuberous Sclerosis 2 (TSC2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Tuberin antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details anti-Tuberin Antibody

Binding Specificity: AA 900-1150

Sequence: CRLPFRKDFV PFITKGLRSN VLLSFDDTPE KDSFRARSTS LNERPKSLRI ARPPKQGLNN SPPVKEFKES SAAEAFRCRS ISVSEHVVRS RIQTSLTSAS LGSADENSVA QADDSLKNLH LELTETCLDM MARYVFSNFT AVPKRSPVGE FLLAGGRTKT WLVGNKLVTV TTSVGTGTRS LLGLDSGELQ SGPESSSSPG VHVRQTKEAP AKLESQAGQQ VSRGARDRVR SMSGGHGLRV GALDVPASQF L

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 900-1150 of human TSC2 (NP_000539.2).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IHC,1:50 - 1:200,IF,1:50 - 1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for Tuberin

Target: Tuberin (TSC2) (Tuberous Sclerosis 2 (TSC2))

Alternative Name: TSC2

Background: Mutations in this gene lead to tuberous sclerosis complex. Its gene product is believed to be a tumor suppressor and is able to stimulate specific GTPases. The protein associates with hamartin in a cytosolic complex, possibly acting as a chaperone for hamartin. Alternative splicing results in multiple transcript variants encoding different isoforms.,LAM,PPP1R160,TSC4,TSC2,Tuberin,tuberin,Epigenetics & Nuclear Signaling,Translation Control,Regulation of eIF4 and p70 S6 Kinase,Cancer,Tumor suppressors,Signal Transduction,G protein signaling,PI3K-Akt Signaling Pathway,mTOR Signaling Pathway,MAPK-Erk Signaling Pathway,Cell Biology & Developmental Biology,Apoptosis,Autophagy,Cell Cycle,Cell cycle inhibitors,Endocrine & Metabolism,AMPK Signaling Pathway,Insulin Receptor Signaling Pathway,Endocrine and metabolic diseases,Obesity,Immunology & Inflammation,Akt downstream targets,Regulators,TSC2

Molecular Weight: 25 kDa/187-200 kDa

Gene ID: 7249

UniProt: P49815

Pathways: RTK Signaling, AMPK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Regulation of Cell Size, Tube Formation, Protein targeting to Nucleus